Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to its translation is lack of performance and reporting standards. The MEtabolomics standaRds Initiative in Toxicology (MERIT) project brings tog...

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Autores principales: Viant, Mark R., Ebbels, Timothy M. D., Beger, Richard D., Ekman, Drew R., Epps, David J. T., Kamp, Hennicke, Leonards, Pim E. G., Loizou, George D., MacRae, James I., van Ravenzwaay, Bennard, Rocca-Serra, Philippe, Salek, Reza M., Walk, Tilmann, Weber, Ralf J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620295/
https://www.ncbi.nlm.nih.gov/pubmed/31292445
http://dx.doi.org/10.1038/s41467-019-10900-y
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author Viant, Mark R.
Ebbels, Timothy M. D.
Beger, Richard D.
Ekman, Drew R.
Epps, David J. T.
Kamp, Hennicke
Leonards, Pim E. G.
Loizou, George D.
MacRae, James I.
van Ravenzwaay, Bennard
Rocca-Serra, Philippe
Salek, Reza M.
Walk, Tilmann
Weber, Ralf J. M.
author_facet Viant, Mark R.
Ebbels, Timothy M. D.
Beger, Richard D.
Ekman, Drew R.
Epps, David J. T.
Kamp, Hennicke
Leonards, Pim E. G.
Loizou, George D.
MacRae, James I.
van Ravenzwaay, Bennard
Rocca-Serra, Philippe
Salek, Reza M.
Walk, Tilmann
Weber, Ralf J. M.
author_sort Viant, Mark R.
collection PubMed
description Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to its translation is lack of performance and reporting standards. The MEtabolomics standaRds Initiative in Toxicology (MERIT) project brings together international experts from multiple sectors to address this need. Here, we identify the most relevant applications for metabolomics in regulatory toxicology and develop best practice guidelines, performance and reporting standards for acquiring and analysing untargeted metabolomics and targeted metabolite data. We recommend that these guidelines are evaluated and implemented for several regulatory use cases.
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spelling pubmed-66202952019-07-15 Use cases, best practice and reporting standards for metabolomics in regulatory toxicology Viant, Mark R. Ebbels, Timothy M. D. Beger, Richard D. Ekman, Drew R. Epps, David J. T. Kamp, Hennicke Leonards, Pim E. G. Loizou, George D. MacRae, James I. van Ravenzwaay, Bennard Rocca-Serra, Philippe Salek, Reza M. Walk, Tilmann Weber, Ralf J. M. Nat Commun Perspective Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to its translation is lack of performance and reporting standards. The MEtabolomics standaRds Initiative in Toxicology (MERIT) project brings together international experts from multiple sectors to address this need. Here, we identify the most relevant applications for metabolomics in regulatory toxicology and develop best practice guidelines, performance and reporting standards for acquiring and analysing untargeted metabolomics and targeted metabolite data. We recommend that these guidelines are evaluated and implemented for several regulatory use cases. Nature Publishing Group UK 2019-07-10 /pmc/articles/PMC6620295/ /pubmed/31292445 http://dx.doi.org/10.1038/s41467-019-10900-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Perspective
Viant, Mark R.
Ebbels, Timothy M. D.
Beger, Richard D.
Ekman, Drew R.
Epps, David J. T.
Kamp, Hennicke
Leonards, Pim E. G.
Loizou, George D.
MacRae, James I.
van Ravenzwaay, Bennard
Rocca-Serra, Philippe
Salek, Reza M.
Walk, Tilmann
Weber, Ralf J. M.
Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
title Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
title_full Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
title_fullStr Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
title_full_unstemmed Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
title_short Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
title_sort use cases, best practice and reporting standards for metabolomics in regulatory toxicology
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620295/
https://www.ncbi.nlm.nih.gov/pubmed/31292445
http://dx.doi.org/10.1038/s41467-019-10900-y
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