Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury

Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injury. This study aims to investigate whether the bene...

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Detalles Bibliográficos
Autores principales: Marek-Iannucci, Stefanie, Thomas, Amandine, Hou, Jean, Crupi, Annunziata, Sin, Jon, Taylor, David J., Czer, Lawrence S., Esmailian, Fardad, Mentzer, Robert M., Andres, Allen M., Gottlieb, Roberta A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620356/
https://www.ncbi.nlm.nih.gov/pubmed/31292486
http://dx.doi.org/10.1038/s41598-019-46452-w

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