Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed T(H)1/T(H)2 Response Independent of Differentiation

The activation mechanism of chimeric antigen receptor (CAR)-engineered T cells may differ substantially from T cells carrying native T cell receptor, but this difference remains poorly understood. We present the first comprehensive portrait of single-cell level transcriptional and cytokine signature...

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Detalles Bibliográficos
Autores principales: Xhangolli, Iva, Dura, Burak, Lee, GeeHee, Kim, Dongjoo, Xiao, Yang, Fan, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620429/
https://www.ncbi.nlm.nih.gov/pubmed/31229590
http://dx.doi.org/10.1016/j.gpb.2019.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620429/
https://www.ncbi.nlm.nih.gov/pubmed/31229590
http://dx.doi.org/10.1016/j.gpb.2019.03.002

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