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Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease
BACKGROUND AND PURPOSE: Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential confounders affecting the nutrit...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Neurological Association
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620466/ https://www.ncbi.nlm.nih.gov/pubmed/31286699 http://dx.doi.org/10.3988/jcn.2019.15.3.292 |
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author | Jang, Jae-Won Kim, Yeshin Choi, Yong-Ho Lee, Jong-Min Yoon, Bora Park, Kyung Won Kim, Si Eun Kim, Hee Jin Yoon, Soo Jin Jeong, Jee Hyang Kim, Eun-Joo Jung, Na Yeon Hwang, Jihye Kang, Ju-Hee Hong, Jin Yong Choi, Seong Hye |
author_facet | Jang, Jae-Won Kim, Yeshin Choi, Yong-Ho Lee, Jong-Min Yoon, Bora Park, Kyung Won Kim, Si Eun Kim, Hee Jin Yoon, Soo Jin Jeong, Jee Hyang Kim, Eun-Joo Jung, Na Yeon Hwang, Jihye Kang, Ju-Hee Hong, Jin Yong Choi, Seong Hye |
author_sort | Jang, Jae-Won |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential confounders affecting the nutritional status. The purpose of the current study was to determine the nutritional status of participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) and to identify clinical risk factors for being at risk of malnutrition or being malnourished. METHODS: Baseline data from 212 participants [119 cognitively unimpaired (CU), 56 with mild cognitive impairment (MCI), and 37 with dementia] included in the KBASE database were analyzed. All participants underwent a comprehensive cognitive test and MRI at baseline. The presence of malnutrition at baseline was measured by the Mini Nutritional Assessment score. We examined the cross-sectional relationships of clinical findings with nutritional status using multiple logistic regression applied to variables for which p<0.2 in the univariate analysis. Differences in cortical thickness according to the nutritional status were also investigated. RESULTS: After adjustment for demographic, nutritional, and neuropsychological factors, participants with dementia had a significantly higher odds ratio (OR) for being at risk of malnutrition or being malnourished than CU participants [OR=5.98, 95% CI=1.20–32.97] whereas participants with MCI did not (OR=0.62, 95% CI=0.20–1.83). Cortical thinning in the at-risk/malnutrition group was observed in the left temporal area. CONCLUSIONS: Dementia was found to be an independent predictor for the risk of malnutrition compared with CU participants. Our findings further suggest that cortical thinning in left temporal regions is related to the nutritional status. |
format | Online Article Text |
id | pubmed-6620466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Neurological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-66204662019-07-23 Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease Jang, Jae-Won Kim, Yeshin Choi, Yong-Ho Lee, Jong-Min Yoon, Bora Park, Kyung Won Kim, Si Eun Kim, Hee Jin Yoon, Soo Jin Jeong, Jee Hyang Kim, Eun-Joo Jung, Na Yeon Hwang, Jihye Kang, Ju-Hee Hong, Jin Yong Choi, Seong Hye J Clin Neurol Original Article BACKGROUND AND PURPOSE: Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential confounders affecting the nutritional status. The purpose of the current study was to determine the nutritional status of participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) and to identify clinical risk factors for being at risk of malnutrition or being malnourished. METHODS: Baseline data from 212 participants [119 cognitively unimpaired (CU), 56 with mild cognitive impairment (MCI), and 37 with dementia] included in the KBASE database were analyzed. All participants underwent a comprehensive cognitive test and MRI at baseline. The presence of malnutrition at baseline was measured by the Mini Nutritional Assessment score. We examined the cross-sectional relationships of clinical findings with nutritional status using multiple logistic regression applied to variables for which p<0.2 in the univariate analysis. Differences in cortical thickness according to the nutritional status were also investigated. RESULTS: After adjustment for demographic, nutritional, and neuropsychological factors, participants with dementia had a significantly higher odds ratio (OR) for being at risk of malnutrition or being malnourished than CU participants [OR=5.98, 95% CI=1.20–32.97] whereas participants with MCI did not (OR=0.62, 95% CI=0.20–1.83). Cortical thinning in the at-risk/malnutrition group was observed in the left temporal area. CONCLUSIONS: Dementia was found to be an independent predictor for the risk of malnutrition compared with CU participants. Our findings further suggest that cortical thinning in left temporal regions is related to the nutritional status. Korean Neurological Association 2019-07 2019-04-02 /pmc/articles/PMC6620466/ /pubmed/31286699 http://dx.doi.org/10.3988/jcn.2019.15.3.292 Text en Copyright © 2019 Korean Neurological Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jang, Jae-Won Kim, Yeshin Choi, Yong-Ho Lee, Jong-Min Yoon, Bora Park, Kyung Won Kim, Si Eun Kim, Hee Jin Yoon, Soo Jin Jeong, Jee Hyang Kim, Eun-Joo Jung, Na Yeon Hwang, Jihye Kang, Ju-Hee Hong, Jin Yong Choi, Seong Hye Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease |
title | Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease |
title_full | Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease |
title_fullStr | Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease |
title_full_unstemmed | Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease |
title_short | Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease |
title_sort | association of nutritional status with cognitive stage in the elderly korean population: the korean brain aging study for the early diagnosis and prediction of alzheimer's disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620466/ https://www.ncbi.nlm.nih.gov/pubmed/31286699 http://dx.doi.org/10.3988/jcn.2019.15.3.292 |
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