Cargando…

Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease

BACKGROUND AND PURPOSE: Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential confounders affecting the nutrit...

Descripción completa

Detalles Bibliográficos
Autores principales: Jang, Jae-Won, Kim, Yeshin, Choi, Yong-Ho, Lee, Jong-Min, Yoon, Bora, Park, Kyung Won, Kim, Si Eun, Kim, Hee Jin, Yoon, Soo Jin, Jeong, Jee Hyang, Kim, Eun-Joo, Jung, Na Yeon, Hwang, Jihye, Kang, Ju-Hee, Hong, Jin Yong, Choi, Seong Hye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurological Association 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620466/
https://www.ncbi.nlm.nih.gov/pubmed/31286699
http://dx.doi.org/10.3988/jcn.2019.15.3.292
_version_ 1783434054676250624
author Jang, Jae-Won
Kim, Yeshin
Choi, Yong-Ho
Lee, Jong-Min
Yoon, Bora
Park, Kyung Won
Kim, Si Eun
Kim, Hee Jin
Yoon, Soo Jin
Jeong, Jee Hyang
Kim, Eun-Joo
Jung, Na Yeon
Hwang, Jihye
Kang, Ju-Hee
Hong, Jin Yong
Choi, Seong Hye
author_facet Jang, Jae-Won
Kim, Yeshin
Choi, Yong-Ho
Lee, Jong-Min
Yoon, Bora
Park, Kyung Won
Kim, Si Eun
Kim, Hee Jin
Yoon, Soo Jin
Jeong, Jee Hyang
Kim, Eun-Joo
Jung, Na Yeon
Hwang, Jihye
Kang, Ju-Hee
Hong, Jin Yong
Choi, Seong Hye
author_sort Jang, Jae-Won
collection PubMed
description BACKGROUND AND PURPOSE: Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential confounders affecting the nutritional status. The purpose of the current study was to determine the nutritional status of participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) and to identify clinical risk factors for being at risk of malnutrition or being malnourished. METHODS: Baseline data from 212 participants [119 cognitively unimpaired (CU), 56 with mild cognitive impairment (MCI), and 37 with dementia] included in the KBASE database were analyzed. All participants underwent a comprehensive cognitive test and MRI at baseline. The presence of malnutrition at baseline was measured by the Mini Nutritional Assessment score. We examined the cross-sectional relationships of clinical findings with nutritional status using multiple logistic regression applied to variables for which p<0.2 in the univariate analysis. Differences in cortical thickness according to the nutritional status were also investigated. RESULTS: After adjustment for demographic, nutritional, and neuropsychological factors, participants with dementia had a significantly higher odds ratio (OR) for being at risk of malnutrition or being malnourished than CU participants [OR=5.98, 95% CI=1.20–32.97] whereas participants with MCI did not (OR=0.62, 95% CI=0.20–1.83). Cortical thinning in the at-risk/malnutrition group was observed in the left temporal area. CONCLUSIONS: Dementia was found to be an independent predictor for the risk of malnutrition compared with CU participants. Our findings further suggest that cortical thinning in left temporal regions is related to the nutritional status.
format Online
Article
Text
id pubmed-6620466
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Korean Neurological Association
record_format MEDLINE/PubMed
spelling pubmed-66204662019-07-23 Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease Jang, Jae-Won Kim, Yeshin Choi, Yong-Ho Lee, Jong-Min Yoon, Bora Park, Kyung Won Kim, Si Eun Kim, Hee Jin Yoon, Soo Jin Jeong, Jee Hyang Kim, Eun-Joo Jung, Na Yeon Hwang, Jihye Kang, Ju-Hee Hong, Jin Yong Choi, Seong Hye J Clin Neurol Original Article BACKGROUND AND PURPOSE: Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential confounders affecting the nutritional status. The purpose of the current study was to determine the nutritional status of participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) and to identify clinical risk factors for being at risk of malnutrition or being malnourished. METHODS: Baseline data from 212 participants [119 cognitively unimpaired (CU), 56 with mild cognitive impairment (MCI), and 37 with dementia] included in the KBASE database were analyzed. All participants underwent a comprehensive cognitive test and MRI at baseline. The presence of malnutrition at baseline was measured by the Mini Nutritional Assessment score. We examined the cross-sectional relationships of clinical findings with nutritional status using multiple logistic regression applied to variables for which p<0.2 in the univariate analysis. Differences in cortical thickness according to the nutritional status were also investigated. RESULTS: After adjustment for demographic, nutritional, and neuropsychological factors, participants with dementia had a significantly higher odds ratio (OR) for being at risk of malnutrition or being malnourished than CU participants [OR=5.98, 95% CI=1.20–32.97] whereas participants with MCI did not (OR=0.62, 95% CI=0.20–1.83). Cortical thinning in the at-risk/malnutrition group was observed in the left temporal area. CONCLUSIONS: Dementia was found to be an independent predictor for the risk of malnutrition compared with CU participants. Our findings further suggest that cortical thinning in left temporal regions is related to the nutritional status. Korean Neurological Association 2019-07 2019-04-02 /pmc/articles/PMC6620466/ /pubmed/31286699 http://dx.doi.org/10.3988/jcn.2019.15.3.292 Text en Copyright © 2019 Korean Neurological Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jang, Jae-Won
Kim, Yeshin
Choi, Yong-Ho
Lee, Jong-Min
Yoon, Bora
Park, Kyung Won
Kim, Si Eun
Kim, Hee Jin
Yoon, Soo Jin
Jeong, Jee Hyang
Kim, Eun-Joo
Jung, Na Yeon
Hwang, Jihye
Kang, Ju-Hee
Hong, Jin Yong
Choi, Seong Hye
Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease
title Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease
title_full Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease
title_fullStr Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease
title_full_unstemmed Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease
title_short Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease
title_sort association of nutritional status with cognitive stage in the elderly korean population: the korean brain aging study for the early diagnosis and prediction of alzheimer's disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620466/
https://www.ncbi.nlm.nih.gov/pubmed/31286699
http://dx.doi.org/10.3988/jcn.2019.15.3.292
work_keys_str_mv AT jangjaewon associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT kimyeshin associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT choiyongho associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT leejongmin associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT yoonbora associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT parkkyungwon associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT kimsieun associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT kimheejin associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT yoonsoojin associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT jeongjeehyang associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT kimeunjoo associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT jungnayeon associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT hwangjihye associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT kangjuhee associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT hongjinyong associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease
AT choiseonghye associationofnutritionalstatuswithcognitivestageintheelderlykoreanpopulationthekoreanbrainagingstudyfortheearlydiagnosisandpredictionofalzheimersdisease