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High-energy guanine nucleotides as a signal capable of linking growth to cellular energy status via the control of gene transcription
This mini-review considers the idea that guanylate nucleotide energy charge acts as an integrative signal for the regulation of gene expression in eukaryotic cells and discusses possible routes for that signal’s transduction. Gene expression is intimately linked with cell nutrition and diverse signa...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620469/ https://www.ncbi.nlm.nih.gov/pubmed/30937517 http://dx.doi.org/10.1007/s00294-019-00963-1 |
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author | Hesketh, Andy Oliver, Stephen G. |
author_facet | Hesketh, Andy Oliver, Stephen G. |
author_sort | Hesketh, Andy |
collection | PubMed |
description | This mini-review considers the idea that guanylate nucleotide energy charge acts as an integrative signal for the regulation of gene expression in eukaryotic cells and discusses possible routes for that signal’s transduction. Gene expression is intimately linked with cell nutrition and diverse signaling systems serve to coordinate the synthesis of proteins required for growth and proliferation with the prevailing cellular nutritional status. Using short pathways for the inducible and futile consumption of ATP or GTP in engineered cells of Saccharomyces cerevisiae, we have recently shown that GTP levels can also play a role in determining how genes act to respond to changes in cellular energy supply. This review aims to interpret the importance of GTP as an integrative signal in the context of an increasing body of evidence indicating the spatio-temporal complexity of cellular de novo purine nucleotide biosynthesis. |
format | Online Article Text |
id | pubmed-6620469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-66204692019-07-28 High-energy guanine nucleotides as a signal capable of linking growth to cellular energy status via the control of gene transcription Hesketh, Andy Oliver, Stephen G. Curr Genet Mini-Review This mini-review considers the idea that guanylate nucleotide energy charge acts as an integrative signal for the regulation of gene expression in eukaryotic cells and discusses possible routes for that signal’s transduction. Gene expression is intimately linked with cell nutrition and diverse signaling systems serve to coordinate the synthesis of proteins required for growth and proliferation with the prevailing cellular nutritional status. Using short pathways for the inducible and futile consumption of ATP or GTP in engineered cells of Saccharomyces cerevisiae, we have recently shown that GTP levels can also play a role in determining how genes act to respond to changes in cellular energy supply. This review aims to interpret the importance of GTP as an integrative signal in the context of an increasing body of evidence indicating the spatio-temporal complexity of cellular de novo purine nucleotide biosynthesis. Springer Berlin Heidelberg 2019-04-01 2019 /pmc/articles/PMC6620469/ /pubmed/30937517 http://dx.doi.org/10.1007/s00294-019-00963-1 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Mini-Review Hesketh, Andy Oliver, Stephen G. High-energy guanine nucleotides as a signal capable of linking growth to cellular energy status via the control of gene transcription |
title | High-energy guanine nucleotides as a signal capable of linking growth to cellular energy status via the control of gene transcription |
title_full | High-energy guanine nucleotides as a signal capable of linking growth to cellular energy status via the control of gene transcription |
title_fullStr | High-energy guanine nucleotides as a signal capable of linking growth to cellular energy status via the control of gene transcription |
title_full_unstemmed | High-energy guanine nucleotides as a signal capable of linking growth to cellular energy status via the control of gene transcription |
title_short | High-energy guanine nucleotides as a signal capable of linking growth to cellular energy status via the control of gene transcription |
title_sort | high-energy guanine nucleotides as a signal capable of linking growth to cellular energy status via the control of gene transcription |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620469/ https://www.ncbi.nlm.nih.gov/pubmed/30937517 http://dx.doi.org/10.1007/s00294-019-00963-1 |
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