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Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity

Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of essential processes in humans from embryonic development to adult tissue homeostasis through interactions with membrane-bound ephrin ligands. The ubiquitous expression of Eph receptors and ephrin ligands among...

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Autores principales: Darling, Thayer K., Lamb, Tracey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620610/
https://www.ncbi.nlm.nih.gov/pubmed/31333644
http://dx.doi.org/10.3389/fimmu.2019.01473
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author Darling, Thayer K.
Lamb, Tracey J.
author_facet Darling, Thayer K.
Lamb, Tracey J.
author_sort Darling, Thayer K.
collection PubMed
description Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of essential processes in humans from embryonic development to adult tissue homeostasis through interactions with membrane-bound ephrin ligands. The ubiquitous expression of Eph receptors and ephrin ligands among the cellular players of the immune system underscores the importance of these molecules in orchestrating an optimal immune response. This review provides an overview of the various roles of Eph receptors and ephrin ligands in immune cell development, activation, and migration. We also discuss the role of Eph receptors in disease pathogenesis as well as the implications of Eph receptors as future immunotherapy targets. Given the diverse and critical roles of Eph receptors and ephrin ligands throughout the immune system during both resting and activated states, this review aims to highlight the critical yet underappreciated roles of this family of signaling molecules in the immune system.
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spelling pubmed-66206102019-07-22 Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity Darling, Thayer K. Lamb, Tracey J. Front Immunol Immunology Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of essential processes in humans from embryonic development to adult tissue homeostasis through interactions with membrane-bound ephrin ligands. The ubiquitous expression of Eph receptors and ephrin ligands among the cellular players of the immune system underscores the importance of these molecules in orchestrating an optimal immune response. This review provides an overview of the various roles of Eph receptors and ephrin ligands in immune cell development, activation, and migration. We also discuss the role of Eph receptors in disease pathogenesis as well as the implications of Eph receptors as future immunotherapy targets. Given the diverse and critical roles of Eph receptors and ephrin ligands throughout the immune system during both resting and activated states, this review aims to highlight the critical yet underappreciated roles of this family of signaling molecules in the immune system. Frontiers Media S.A. 2019-07-04 /pmc/articles/PMC6620610/ /pubmed/31333644 http://dx.doi.org/10.3389/fimmu.2019.01473 Text en Copyright © 2019 Darling and Lamb. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Darling, Thayer K.
Lamb, Tracey J.
Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
title Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
title_full Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
title_fullStr Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
title_full_unstemmed Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
title_short Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
title_sort emerging roles for eph receptors and ephrin ligands in immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620610/
https://www.ncbi.nlm.nih.gov/pubmed/31333644
http://dx.doi.org/10.3389/fimmu.2019.01473
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