Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy

Invasive aspergillosis (IA) is a serious condition that can affect almost any organ. Cerebral aspergillosis itself is rapidly fatal without treatment. We report a case of disseminated cerebral IA in a patient exposed to cyclophosphamide, rituximab and prednisone. This case is unique because: 1) diss...

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Autores principales: Lester, Robynn, Church, Deirdre, Ambasta, Anshula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620712/
https://www.ncbi.nlm.nih.gov/pubmed/31334000
http://dx.doi.org/10.1016/j.mmcr.2019.07.002
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author Lester, Robynn
Church, Deirdre
Ambasta, Anshula
author_facet Lester, Robynn
Church, Deirdre
Ambasta, Anshula
author_sort Lester, Robynn
collection PubMed
description Invasive aspergillosis (IA) is a serious condition that can affect almost any organ. Cerebral aspergillosis itself is rapidly fatal without treatment. We report a case of disseminated cerebral IA in a patient exposed to cyclophosphamide, rituximab and prednisone. This case is unique because: 1) disseminated IA has not been described in anti-glomerular basement membrane glomerulonephritis; 2) IA led to thrombotic microangiopathy with normal ADAMTS13 and 3) voriconazole toxicity necessitated use of isavuconazole for IA treatment.
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spelling pubmed-66207122019-07-22 Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy Lester, Robynn Church, Deirdre Ambasta, Anshula Med Mycol Case Rep Case Report Invasive aspergillosis (IA) is a serious condition that can affect almost any organ. Cerebral aspergillosis itself is rapidly fatal without treatment. We report a case of disseminated cerebral IA in a patient exposed to cyclophosphamide, rituximab and prednisone. This case is unique because: 1) disseminated IA has not been described in anti-glomerular basement membrane glomerulonephritis; 2) IA led to thrombotic microangiopathy with normal ADAMTS13 and 3) voriconazole toxicity necessitated use of isavuconazole for IA treatment. Elsevier 2019-07-05 /pmc/articles/PMC6620712/ /pubmed/31334000 http://dx.doi.org/10.1016/j.mmcr.2019.07.002 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Lester, Robynn
Church, Deirdre
Ambasta, Anshula
Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
title Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
title_full Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
title_fullStr Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
title_full_unstemmed Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
title_short Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
title_sort disseminated cerebral aspergillosis complicated by thrombotic microangiopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620712/
https://www.ncbi.nlm.nih.gov/pubmed/31334000
http://dx.doi.org/10.1016/j.mmcr.2019.07.002
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AT ambastaanshula disseminatedcerebralaspergillosiscomplicatedbythromboticmicroangiopathy

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