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Interferon-Inducible Protein 16 (IFI16) Has a Broad-Spectrum Binding Ability Against ssDNA Targets: An Evolutionary Hypothesis for Antiretroviral Checkpoint
Human endogenous retroviruses (HERVs) are under genomic and epigenetic control but can be expressed in normal tissues, producing RNA transcripts some of which are translated. While it has not been demonstrated experimentally in modern humans, cDNA copies from HERV RNA (namely HERV-K HML-2 or HK2) we...
Autores principales: | Hurst, Tara Patricia, Aswad, Amr, Karamitros, Timokratis, Katzourakis, Aris, Smith, Adrian L., Magiorkinis, Gkikas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621918/ https://www.ncbi.nlm.nih.gov/pubmed/31333597 http://dx.doi.org/10.3389/fmicb.2019.01426 |
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