Inactivation of Prostaglandin E(2) as a Mechanism for UGT2B17-Mediated Adverse Effects in Chronic Lymphocytic Leukemia

High expression of the metabolic enzyme UDP-glucuronosyltransferase UGT2B17 in chronic lymphocytic leukemia (CLL) cells was associated with poor prognosis in two independent studies. However, the underlying mechanism remains unknown. We hypothesized that UGT2B17 impacts intracellular levels of hormo...

Descripción completa

Detalles Bibliográficos
Autores principales: Allain, Eric P., Rouleau, Michèle, Le, Trang, Vanura, Katrina, Villeneuve, Lyne, Caron, Patrick, Turcotte, Véronique, Lévesque, Eric, Guillemette, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621974/
https://www.ncbi.nlm.nih.gov/pubmed/31334126
http://dx.doi.org/10.3389/fonc.2019.00606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621974/
https://www.ncbi.nlm.nih.gov/pubmed/31334126
http://dx.doi.org/10.3389/fonc.2019.00606

Ejemplares similares