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Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children

OBJECTIVES: To analyse the internal consistency of an adaption of the methotrexate intolerance severity score (MISS); and to describe and compare the level of methotrexate intolerance evaluated by the MISS in Danish children with juvenile idiopathic arthritis (JIA) or acute lymphoblastic leukaemia (...

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Autores principales: Kyvsgaard, Nini, Mikkelsen, Torben Stamm, Thastum, Mikael, Christensen, Anne Estmann, Wehner, Peder Skov, Nysom, Karsten, Herlin, Troels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622540/
https://www.ncbi.nlm.nih.gov/pubmed/31295288
http://dx.doi.org/10.1371/journal.pone.0219539
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author Kyvsgaard, Nini
Mikkelsen, Torben Stamm
Thastum, Mikael
Christensen, Anne Estmann
Wehner, Peder Skov
Nysom, Karsten
Herlin, Troels
author_facet Kyvsgaard, Nini
Mikkelsen, Torben Stamm
Thastum, Mikael
Christensen, Anne Estmann
Wehner, Peder Skov
Nysom, Karsten
Herlin, Troels
author_sort Kyvsgaard, Nini
collection PubMed
description OBJECTIVES: To analyse the internal consistency of an adaption of the methotrexate intolerance severity score (MISS); and to describe and compare the level of methotrexate intolerance evaluated by the MISS in Danish children with juvenile idiopathic arthritis (JIA) or acute lymphoblastic leukaemia (ALL), treated with low-dose methotrexate (MTX). METHODS: Cross-sectional study of children diagnosed with JIA or ALL, treated with low-dose MTX, aged 9 years or above, and cognitively intact. The patient’s parents completed the MISS. MTX intolerance was defined as a total MISS score above 6. RESULTS: We enrolled 120 children with JIA and 23 children with ALL. The MISS had a good internal consistency in the JIA group. The median MISS score was higher in the JIA group than in the ALL group (JIA: 8; ALL: 1; p<0.0001); and the JIA group had a larger proportion of MTX intolerant children than the ALL group (JIA: 73/120; ALL: 4/23; p<0.001). Within both the JIA group and the ALL group, the MISS total score was not significantly correlated with age, MTX dose or the duration of low-dose MTX treatment. CONCLUSION: In the JIA group the level of MTX intolerance was higher and more attributed to anticipatory, associative and behavioural symptoms than in the ALL group. The MISS may help to uncover whether MTX intolerance is present and which aspects are affected in the individual patient, thus guiding intervention. The MISS may also be applicable within leukaemia care.
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spelling pubmed-66225402019-07-25 Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children Kyvsgaard, Nini Mikkelsen, Torben Stamm Thastum, Mikael Christensen, Anne Estmann Wehner, Peder Skov Nysom, Karsten Herlin, Troels PLoS One Research Article OBJECTIVES: To analyse the internal consistency of an adaption of the methotrexate intolerance severity score (MISS); and to describe and compare the level of methotrexate intolerance evaluated by the MISS in Danish children with juvenile idiopathic arthritis (JIA) or acute lymphoblastic leukaemia (ALL), treated with low-dose methotrexate (MTX). METHODS: Cross-sectional study of children diagnosed with JIA or ALL, treated with low-dose MTX, aged 9 years or above, and cognitively intact. The patient’s parents completed the MISS. MTX intolerance was defined as a total MISS score above 6. RESULTS: We enrolled 120 children with JIA and 23 children with ALL. The MISS had a good internal consistency in the JIA group. The median MISS score was higher in the JIA group than in the ALL group (JIA: 8; ALL: 1; p<0.0001); and the JIA group had a larger proportion of MTX intolerant children than the ALL group (JIA: 73/120; ALL: 4/23; p<0.001). Within both the JIA group and the ALL group, the MISS total score was not significantly correlated with age, MTX dose or the duration of low-dose MTX treatment. CONCLUSION: In the JIA group the level of MTX intolerance was higher and more attributed to anticipatory, associative and behavioural symptoms than in the ALL group. The MISS may help to uncover whether MTX intolerance is present and which aspects are affected in the individual patient, thus guiding intervention. The MISS may also be applicable within leukaemia care. Public Library of Science 2019-07-11 /pmc/articles/PMC6622540/ /pubmed/31295288 http://dx.doi.org/10.1371/journal.pone.0219539 Text en © 2019 Kyvsgaard et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kyvsgaard, Nini
Mikkelsen, Torben Stamm
Thastum, Mikael
Christensen, Anne Estmann
Wehner, Peder Skov
Nysom, Karsten
Herlin, Troels
Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children
title Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children
title_full Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children
title_fullStr Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children
title_full_unstemmed Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children
title_short Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children
title_sort increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622540/
https://www.ncbi.nlm.nih.gov/pubmed/31295288
http://dx.doi.org/10.1371/journal.pone.0219539
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