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Full atomistic model of prion structure and conversion

Prions are unusual protein assemblies that propagate their conformationally-encoded information in absence of nucleic acids. The first prion identified, the scrapie isoform (PrP(Sc)) of the cellular prion protein (PrP(C)), caused epidemic and epizootic episodes [1]. Most aggregates of other misfoldi...

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Detalles Bibliográficos
Autores principales:	Spagnolli, Giovanni, Rigoli, Marta, Orioli, Simone, Sevillano, Alejandro M., Faccioli, Pietro, Wille, Holger, Biasini, Emiliano, Requena, Jesús R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622554/ https://www.ncbi.nlm.nih.gov/pubmed/31295325 http://dx.doi.org/10.1371/journal.ppat.1007864

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