Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila

Inflammasomes are cytosolic multi-protein complexes that detect infection or cellular damage and activate the Caspase-1 (CASP1) protease. The NAIP5/NLRC4 inflammasome detects bacterial flagellin and is essential for resistance to the flagellated intracellular bacterium Legionella pneumophila. The ef...

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Detalles Bibliográficos
Autores principales: Gonçalves, Augusto V., Margolis, Shally R., Quirino, Gustavo F. S., Mascarenhas, Danielle P. A., Rauch, Isabella, Nichols, Randilea D., Ansaldo, Eduard, Fontana, Mary F., Vance, Russell E., Zamboni, Dario S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622555/
https://www.ncbi.nlm.nih.gov/pubmed/31251782
http://dx.doi.org/10.1371/journal.ppat.1007886

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