Cargando…

Low maternal care enhances the skin barrier resistance of offspring in mice

Deprivation of maternal care via lack of somatosensory input causes offspring to experience adverse consequences, especially in the central nervous system. However, little is known about the developmental effect of maternal care on peripheral tissues such as the skin, which includes cutaneous sensor...

Descripción completa

Detalles Bibliográficos
Autores principales: Sakamoto, Takashi, Ishio, Yukino, Ishida, Yuiko, Mogi, Kazutaka, Kikusui, Takefumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624014/
https://www.ncbi.nlm.nih.gov/pubmed/31295326
http://dx.doi.org/10.1371/journal.pone.0219674
_version_ 1783434190133395456
author Sakamoto, Takashi
Ishio, Yukino
Ishida, Yuiko
Mogi, Kazutaka
Kikusui, Takefumi
author_facet Sakamoto, Takashi
Ishio, Yukino
Ishida, Yuiko
Mogi, Kazutaka
Kikusui, Takefumi
author_sort Sakamoto, Takashi
collection PubMed
description Deprivation of maternal care via lack of somatosensory input causes offspring to experience adverse consequences, especially in the central nervous system. However, little is known about the developmental effect of maternal care on peripheral tissues such as the skin, which includes cutaneous sensory neurons. In the present study, we examined the involvement of maternal care in the development of the skin. We investigated offspring reared by early-weaned mother mice who spontaneously showed lower frequency of licking/grooming on nursing. Offspring of early-weaned mothers showed higher resistance against skin barrier disruption than did offspring of normally-weaned mothers, and had normal skin barrier function in the intact trunk skin. In the dorsal root ganglion of early-weaned mother offspring, we also found up-regulation of mRNA levels of the Mas-related G-protein coupled receptor B4 (MrgprB4), which is a marker of sensory neurons that detect gentle stroking. We further found that levels of MrgprB4 mRNA were correlated with the enhancement of skin resistance. The present findings suggest that maternal somatosensory inputs have a developmental impact on the cutaneous sensory neurons of the skin in offspring. Interestingly, the present results suggest that lower maternal care has a benefit on the skin resistance. This provides important information for understanding the development of peripheral tissues in offspring reared under severe conditions such as lower maternal care in the wild.
format Online
Article
Text
id pubmed-6624014
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-66240142019-07-25 Low maternal care enhances the skin barrier resistance of offspring in mice Sakamoto, Takashi Ishio, Yukino Ishida, Yuiko Mogi, Kazutaka Kikusui, Takefumi PLoS One Research Article Deprivation of maternal care via lack of somatosensory input causes offspring to experience adverse consequences, especially in the central nervous system. However, little is known about the developmental effect of maternal care on peripheral tissues such as the skin, which includes cutaneous sensory neurons. In the present study, we examined the involvement of maternal care in the development of the skin. We investigated offspring reared by early-weaned mother mice who spontaneously showed lower frequency of licking/grooming on nursing. Offspring of early-weaned mothers showed higher resistance against skin barrier disruption than did offspring of normally-weaned mothers, and had normal skin barrier function in the intact trunk skin. In the dorsal root ganglion of early-weaned mother offspring, we also found up-regulation of mRNA levels of the Mas-related G-protein coupled receptor B4 (MrgprB4), which is a marker of sensory neurons that detect gentle stroking. We further found that levels of MrgprB4 mRNA were correlated with the enhancement of skin resistance. The present findings suggest that maternal somatosensory inputs have a developmental impact on the cutaneous sensory neurons of the skin in offspring. Interestingly, the present results suggest that lower maternal care has a benefit on the skin resistance. This provides important information for understanding the development of peripheral tissues in offspring reared under severe conditions such as lower maternal care in the wild. Public Library of Science 2019-07-11 /pmc/articles/PMC6624014/ /pubmed/31295326 http://dx.doi.org/10.1371/journal.pone.0219674 Text en © 2019 Sakamoto et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sakamoto, Takashi
Ishio, Yukino
Ishida, Yuiko
Mogi, Kazutaka
Kikusui, Takefumi
Low maternal care enhances the skin barrier resistance of offspring in mice
title Low maternal care enhances the skin barrier resistance of offspring in mice
title_full Low maternal care enhances the skin barrier resistance of offspring in mice
title_fullStr Low maternal care enhances the skin barrier resistance of offspring in mice
title_full_unstemmed Low maternal care enhances the skin barrier resistance of offspring in mice
title_short Low maternal care enhances the skin barrier resistance of offspring in mice
title_sort low maternal care enhances the skin barrier resistance of offspring in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624014/
https://www.ncbi.nlm.nih.gov/pubmed/31295326
http://dx.doi.org/10.1371/journal.pone.0219674
work_keys_str_mv AT sakamototakashi lowmaternalcareenhancestheskinbarrierresistanceofoffspringinmice
AT ishioyukino lowmaternalcareenhancestheskinbarrierresistanceofoffspringinmice
AT ishidayuiko lowmaternalcareenhancestheskinbarrierresistanceofoffspringinmice
AT mogikazutaka lowmaternalcareenhancestheskinbarrierresistanceofoffspringinmice
AT kikusuitakefumi lowmaternalcareenhancestheskinbarrierresistanceofoffspringinmice