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Structural and mutational analysis of the ribosome-arresting human XBP1u

XBP1u, a central component of the unfolded protein response (UPR), is a mammalian protein containing a functionally critical translational arrest peptide (AP). Here, we present a 3 Å cryo-EM structure of the stalled human XBP1u AP. It forms a unique turn in the ribosomal exit tunnel proximal to the...

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Detalles Bibliográficos
Autores principales:	Shanmuganathan, Vivekanandan, Schiller, Nina, Magoulopoulou, Anastasia, Cheng, Jingdong, Braunger, Katharina, Cymer, Florian, Berninghausen, Otto, Beatrix, Birgitta, Kohno, Kenji, von Heijne, Gunnar, Beckmann, Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624018/ https://www.ncbi.nlm.nih.gov/pubmed/31246176 http://dx.doi.org/10.7554/eLife.46267

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