Cargando…

Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein

Most neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV) target the receptor-binding domain (RBD) of the spike glycoprotein and block its binding to the cellular receptor dipeptidyl peptidase 4 (DPP4). The epitopes and mechanisms of mAbs targeting non-RBD regions...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Haixia, Chen, Yingzhu, Zhang, Shuyuan, Niu, Peihua, Qin, Kun, Jia, Wenxu, Huang, Baoying, Zhang, Senyan, Lan, Jun, Zhang, Linqi, Tan, Wenjie, Wang, Xinquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624210/ https://www.ncbi.nlm.nih.gov/pubmed/31296843 http://dx.doi.org/10.1038/s41467-019-10897-4

Ejemplares similares

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein
por: Zhang, Senyan, et al.
Publicado: (2018)

Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein
por: Zhang, Shuyuan, et al.
Publicado: (2022)

Crystallization and Structural Determination of the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein
por: Zhou, Haixia, et al.
Publicado: (2019)

A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein
por: Chen, Yingzhu, et al.
Publicado: (2017)

A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein
por: Chen, Yingzhu, et al.
Publicado: (2017)

Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27
por: Yu, Xiaojuan, et al.
Publicado: (2015)

Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution
por: Zhang, Shuyuan, et al.
Publicado: (2021)

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4
por: Wang, Nianshuang, et al.
Publicado: (2013)

Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD
por: Wang, Nianshuang, et al.
Publicado: (2019)

The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition
por: Qiao, Shuyuan, et al.
Publicado: (2022)

Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection
por: Jia, Wenxu, et al.
Publicado: (2019)

Antibodies and vaccines against Middle East respiratory syndrome coronavirus
por: Xu, Jiuyang, et al.
Publicado: (2019)

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit
por: Hurlburt, Nicholas K., et al.
Publicado: (2022)

Computer aided prediction and identification of potential epitopes in the receptor binding domain (RBD) of spike (S) glycoprotein of MERS-CoV
por: ali, Mohammad Tuhin, et al.
Publicado: (2014)

Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution
por: Yu, Jinfang, et al.
Publicado: (2020)

The recombinant N-terminal domain of spike proteins is a potential vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV) infection
por: Jiaming, Lan, et al.
Publicado: (2017)

Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein
por: Bianchini, Filippo, et al.
Publicado: (2023)

Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins
por: Wang, Zijun, et al.
Publicado: (2022)

Variations in Spike Glycoprotein Gene of MERS-CoV, South Korea, 2015
por: Kim, Dae-Won, et al.
Publicado: (2016)

Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors
por: Park, Young-Jun, et al.
Publicado: (2019)

Identification of a Neutralizing Epitope on TOSV Gn Glycoprotein
por: Gandolfo, Claudia, et al.
Publicado: (2021)

Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
por: Widjaja, Ivy, et al.
Publicado: (2019)

Amino acids within hypervariable region 1 of avian coronavirus IBV (Massachusetts serotype) spike glycoprotein are associated with neutralization epitopes
por: Cavanagh, David, et al.
Publicado: (1988)

A New Neutralization Epitope in the Spike Protein of Porcine Epidemic Diarrhea Virus
por: Liu, Jianbo, et al.
Publicado: (2022)

Identification of the immunodominant neutralizing regions in the spike glycoprotein of porcine deltacoronavirus
por: Chen, Rui, et al.
Publicado: (2020)

Structural definition of a conserved neutralization epitope on HIV-1 gp120
por: Zhou, Tongqing, et al.
Publicado: (2007)

Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2
por: Zhang, Shuyuan, et al.
Publicado: (2022)

Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding
por: Gui, Miao, et al.
Publicado: (2017)

Rational Design of SARS-CoV-2 Spike Glycoproteins To Increase Immunogenicity By T Cell Epitope Engineering
por: Ong, Edison, et al.
Publicado: (2020)

Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineering
por: Ong, Edison, et al.
Publicado: (2020)

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
por: Yuan, Yuan, et al.
Publicado: (2017)

Spiking the MERS-coronavirus receptor
por: Bosch, Berend Jan, et al.
Publicado: (2013)

Immunogenic Epitope-Based Vaccine Prediction from Surface Glycoprotein of MERS-CoV by Deploying Immunoinformatics Approach
por: Nguyen, Truc Ly, et al.
Publicado: (2022)

Localization of major neutralizing epitopes on the S1 polypeptide of the murine coronavirus peplomer glycoprotein
por: Sayaka, Takase-Yoden, et al.
Publicado: (1991)

Localization of the virus neutralizing and hemagglutinin epitopes of E1 glycoprotein of rubella virus
por: Chaye, Helena, et al.
Publicado: (1992)

In Silico Analysis of Neutralizing Antibody Epitopes on The Hepatitis C Virus Surface Glycoproteins
por: Zareh-Khoshchehreh, Raziyeh, et al.
Publicado: (2023)

Novel lamprey antibody recognizes terminal sulfated galactose epitopes on mammalian glycoproteins
por: McKitrick, Tanya R., et al.
Publicado: (2021)

Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins
por: Wang, Zijun, et al.
Publicado: (2022)

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein
por: Li, Yan, et al.
Publicado: (2015)

Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein
por: Zhong, Lilin, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_k4tn6n7jq4nvh9ag5gf2lq8r7e