Crystal structures of Rea1-MIDAS bound to its ribosome assembly factor ligands resembling integrin–ligand-type complexes

The Rea1 AAA(+)-ATPase dislodges assembly factors from pre-60S ribosomes upon ATP hydrolysis, thereby driving ribosome biogenesis. Here, we present crystal structures of Rea1-MIDAS, the conserved domain at the tip of the flexible Rea1 tail, alone and in complex with its substrate ligands, the UBL do...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmed, Yasar Luqman, Thoms, Matthias, Mitterer, Valentin, Sinning, Irmgard, Hurt, Ed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624252/
https://www.ncbi.nlm.nih.gov/pubmed/31296859
http://dx.doi.org/10.1038/s41467-019-10922-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624252/
https://www.ncbi.nlm.nih.gov/pubmed/31296859
http://dx.doi.org/10.1038/s41467-019-10922-6

Ejemplares similares