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Identification of GSK3β inhibitor kenpaullone as a temozolomide enhancer against glioblastoma

Cancer stem cells are associated with chemoresistance and rapid recurrence of malignant tumors, including glioblastoma (GBM). Although temozolomide (TMZ) is the most effective drug treatment for GBM, GBM cells acquire resistance and become refractory to TMZ during treatment. Therefore, glioma stem c...

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Detalles Bibliográficos
Autores principales:	Kitabayashi, Tomohiro, Dong, Yu, Furuta, Takuya, Sabit, Hemragul, Jiapaer, Shabierjiang, Zhang, Jiakang, Zhang, Guangtao, Hayashi, Yasuhiko, Kobayashi, Masahiko, Domoto, Takahiro, Minamoto, Toshinari, Hirao, Atsushi, Nakada, Mitsutoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624278/ https://www.ncbi.nlm.nih.gov/pubmed/31296906 http://dx.doi.org/10.1038/s41598-019-46454-8

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