Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates peptidoglycan synthesis, but this function alone does not explain its essentiality. Here, to further understand WalKR function, we investigate a suppressor mutant that arose when...

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Detalles Bibliográficos
Autores principales: Monk, Ian R., Shaikh, Nausad, Begg, Stephanie L., Gajdiss, Mike, Sharkey, Liam K. R., Lee, Jean Y. H., Pidot, Sacha J., Seemann, Torsten, Kuiper, Michael, Winnen, Brit, Hvorup, Rikki, Collins, Brett M., Bierbaum, Gabriele, Udagedara, Saumya R., Morey, Jacqueline R., Pulyani, Neha, Howden, Benjamin P., Maher, Megan J., McDevitt, Christopher A., King, Glenn F., Stinear, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624279/
https://www.ncbi.nlm.nih.gov/pubmed/31296851
http://dx.doi.org/10.1038/s41467-019-10932-4

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