PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner

The prime function of nucleoli is ribogenesis, however, several other, non-canonical functions have recently been identified, including a role in genotoxic stress response. Upon DNA damage, numerous proteins shuttle dynamically between the nucleolus and the nucleoplasm, yet the underlying molecular...

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Detalles Bibliográficos
Autores principales: Veith, Sebastian, Schink, Andrea, Engbrecht, Marina, Mack, Matthias, Rank, Lisa, Rossatti, Pascal, Hakobyan, Mariam, Goly, Denise, Hefele, Tanja, Frensch, Marco, Fischbach, Arthur, Bürkle, Alexander, Mangerich, Aswin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624289/
https://www.ncbi.nlm.nih.gov/pubmed/31296950
http://dx.doi.org/10.1038/s41598-019-46358-7

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