Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform

Extracellular matrix (ECM)-adhesion proteins and actin cytoskeleton are pivotal in cancer cell invasion. Ras Suppressor-1 (RSU-1), a cell-ECM adhesion protein that interacts with PINCH-1, thus being connected to Integrin Linked Kinase (ILK), alpha-parvin (PARVA), and actin cytoskeleton, is up-regula...

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Detalles Bibliográficos
Autores principales: Gkretsi, Vasiliki, Kalli, Maria, Efstathiades, Christodoulos, Papageorgis, Panagiotis, Papanikolaou, Vassilios, Zacharia, Lefteris C., Tsezou, Aspasia, Athanassiou, Evangelos, Stylianopoulos, Triantafyllos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624310/
https://www.ncbi.nlm.nih.gov/pubmed/31296919
http://dx.doi.org/10.1038/s41598-019-46575-0

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