Quantification of the flux of tyrosine pathway metabolites during nitisinone treatment of Alkaptonuria

Nitisinone decreases homogentisic acid (HGA) in Alkaptonuria (AKU) by inhibiting the tyrosine metabolic pathway in humans. The effect of different daily doses of nitisinone on circulating and 24 h urinary excretion of phenylalanine (PA), tyrosine (TYR), hydroxyphenylpyruvate (HPPA), hydroxyphenyllac...

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Detalles Bibliográficos
Autores principales: Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Rovensky, J., Psarelli, E. E., Cox, T. F., Rhodes, N. P., Gallagher, J. A., Ranganath, L. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624311/
https://www.ncbi.nlm.nih.gov/pubmed/31296884
http://dx.doi.org/10.1038/s41598-019-46033-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624311/
https://www.ncbi.nlm.nih.gov/pubmed/31296884
http://dx.doi.org/10.1038/s41598-019-46033-x

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