Data on the expression of SRPK1a in mammals

SRPK1 is an evolutionary conserved protein kinase that specifically phosphorylates its substrates at serine residues located within arginine-serine-rich (RS) domains. We have previously reported the existence of a second less abundant isoform in humans, SRPK1a, which is formed from alternative splic...

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Detalles Bibliográficos
Autores principales: Vlassi, Metaxia, Kyritsis, Konstantinos A., Vizirianakis, Ioannis S., Giannakouros, Thomas, Aivaliotis, Michalis, Nikolakaki, Eleni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Molecular Phylogenetics and Evolution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624410/
https://www.ncbi.nlm.nih.gov/pubmed/31334320
http://dx.doi.org/10.1016/j.dib.2019.104210
Descripción
Sumario:SRPK1 is an evolutionary conserved protein kinase that specifically phosphorylates its substrates at serine residues located within arginine-serine-rich (RS) domains. We have previously reported the existence of a second less abundant isoform in humans, SRPK1a, which is formed from alternative splicing of the SRPK1 gene and contains an insertion of 171 amino acids at its N-terminal domain (Nikolakaki et al., 2001). In the NCBI database SRPK1a is annotated as a related to SRPK1-mRNA sequence coding for protein CAC39299.1. Here, we present data on the conservation of the extra sequence of SRPK1a in mammals. Furthermore, the retrieved sequences were comparatively analyzed and data on their evolutionary origin and relationships are also presented.

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