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Data on the expression of SRPK1a in mammals

SRPK1 is an evolutionary conserved protein kinase that specifically phosphorylates its substrates at serine residues located within arginine-serine-rich (RS) domains. We have previously reported the existence of a second less abundant isoform in humans, SRPK1a, which is formed from alternative splic...

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Autores principales: Vlassi, Metaxia, Kyritsis, Konstantinos A., Vizirianakis, Ioannis S., Giannakouros, Thomas, Aivaliotis, Michalis, Nikolakaki, Eleni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624410/
https://www.ncbi.nlm.nih.gov/pubmed/31334320
http://dx.doi.org/10.1016/j.dib.2019.104210
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author Vlassi, Metaxia
Kyritsis, Konstantinos A.
Vizirianakis, Ioannis S.
Giannakouros, Thomas
Aivaliotis, Michalis
Nikolakaki, Eleni
author_facet Vlassi, Metaxia
Kyritsis, Konstantinos A.
Vizirianakis, Ioannis S.
Giannakouros, Thomas
Aivaliotis, Michalis
Nikolakaki, Eleni
author_sort Vlassi, Metaxia
collection PubMed
description SRPK1 is an evolutionary conserved protein kinase that specifically phosphorylates its substrates at serine residues located within arginine-serine-rich (RS) domains. We have previously reported the existence of a second less abundant isoform in humans, SRPK1a, which is formed from alternative splicing of the SRPK1 gene and contains an insertion of 171 amino acids at its N-terminal domain (Nikolakaki et al., 2001). In the NCBI database SRPK1a is annotated as a related to SRPK1-mRNA sequence coding for protein CAC39299.1. Here, we present data on the conservation of the extra sequence of SRPK1a in mammals. Furthermore, the retrieved sequences were comparatively analyzed and data on their evolutionary origin and relationships are also presented.
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spelling pubmed-66244102019-07-22 Data on the expression of SRPK1a in mammals Vlassi, Metaxia Kyritsis, Konstantinos A. Vizirianakis, Ioannis S. Giannakouros, Thomas Aivaliotis, Michalis Nikolakaki, Eleni Data Brief Molecular Phylogenetics and Evolution SRPK1 is an evolutionary conserved protein kinase that specifically phosphorylates its substrates at serine residues located within arginine-serine-rich (RS) domains. We have previously reported the existence of a second less abundant isoform in humans, SRPK1a, which is formed from alternative splicing of the SRPK1 gene and contains an insertion of 171 amino acids at its N-terminal domain (Nikolakaki et al., 2001). In the NCBI database SRPK1a is annotated as a related to SRPK1-mRNA sequence coding for protein CAC39299.1. Here, we present data on the conservation of the extra sequence of SRPK1a in mammals. Furthermore, the retrieved sequences were comparatively analyzed and data on their evolutionary origin and relationships are also presented. Elsevier 2019-07-03 /pmc/articles/PMC6624410/ /pubmed/31334320 http://dx.doi.org/10.1016/j.dib.2019.104210 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Molecular Phylogenetics and Evolution
Vlassi, Metaxia
Kyritsis, Konstantinos A.
Vizirianakis, Ioannis S.
Giannakouros, Thomas
Aivaliotis, Michalis
Nikolakaki, Eleni
Data on the expression of SRPK1a in mammals
title Data on the expression of SRPK1a in mammals
title_full Data on the expression of SRPK1a in mammals
title_fullStr Data on the expression of SRPK1a in mammals
title_full_unstemmed Data on the expression of SRPK1a in mammals
title_short Data on the expression of SRPK1a in mammals
title_sort data on the expression of srpk1a in mammals
topic Molecular Phylogenetics and Evolution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624410/
https://www.ncbi.nlm.nih.gov/pubmed/31334320
http://dx.doi.org/10.1016/j.dib.2019.104210
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