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Data on the expression of SRPK1a in mammals
SRPK1 is an evolutionary conserved protein kinase that specifically phosphorylates its substrates at serine residues located within arginine-serine-rich (RS) domains. We have previously reported the existence of a second less abundant isoform in humans, SRPK1a, which is formed from alternative splic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624410/ https://www.ncbi.nlm.nih.gov/pubmed/31334320 http://dx.doi.org/10.1016/j.dib.2019.104210 |
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author | Vlassi, Metaxia Kyritsis, Konstantinos A. Vizirianakis, Ioannis S. Giannakouros, Thomas Aivaliotis, Michalis Nikolakaki, Eleni |
author_facet | Vlassi, Metaxia Kyritsis, Konstantinos A. Vizirianakis, Ioannis S. Giannakouros, Thomas Aivaliotis, Michalis Nikolakaki, Eleni |
author_sort | Vlassi, Metaxia |
collection | PubMed |
description | SRPK1 is an evolutionary conserved protein kinase that specifically phosphorylates its substrates at serine residues located within arginine-serine-rich (RS) domains. We have previously reported the existence of a second less abundant isoform in humans, SRPK1a, which is formed from alternative splicing of the SRPK1 gene and contains an insertion of 171 amino acids at its N-terminal domain (Nikolakaki et al., 2001). In the NCBI database SRPK1a is annotated as a related to SRPK1-mRNA sequence coding for protein CAC39299.1. Here, we present data on the conservation of the extra sequence of SRPK1a in mammals. Furthermore, the retrieved sequences were comparatively analyzed and data on their evolutionary origin and relationships are also presented. |
format | Online Article Text |
id | pubmed-6624410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-66244102019-07-22 Data on the expression of SRPK1a in mammals Vlassi, Metaxia Kyritsis, Konstantinos A. Vizirianakis, Ioannis S. Giannakouros, Thomas Aivaliotis, Michalis Nikolakaki, Eleni Data Brief Molecular Phylogenetics and Evolution SRPK1 is an evolutionary conserved protein kinase that specifically phosphorylates its substrates at serine residues located within arginine-serine-rich (RS) domains. We have previously reported the existence of a second less abundant isoform in humans, SRPK1a, which is formed from alternative splicing of the SRPK1 gene and contains an insertion of 171 amino acids at its N-terminal domain (Nikolakaki et al., 2001). In the NCBI database SRPK1a is annotated as a related to SRPK1-mRNA sequence coding for protein CAC39299.1. Here, we present data on the conservation of the extra sequence of SRPK1a in mammals. Furthermore, the retrieved sequences were comparatively analyzed and data on their evolutionary origin and relationships are also presented. Elsevier 2019-07-03 /pmc/articles/PMC6624410/ /pubmed/31334320 http://dx.doi.org/10.1016/j.dib.2019.104210 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Molecular Phylogenetics and Evolution Vlassi, Metaxia Kyritsis, Konstantinos A. Vizirianakis, Ioannis S. Giannakouros, Thomas Aivaliotis, Michalis Nikolakaki, Eleni Data on the expression of SRPK1a in mammals |
title | Data on the expression of SRPK1a in mammals |
title_full | Data on the expression of SRPK1a in mammals |
title_fullStr | Data on the expression of SRPK1a in mammals |
title_full_unstemmed | Data on the expression of SRPK1a in mammals |
title_short | Data on the expression of SRPK1a in mammals |
title_sort | data on the expression of srpk1a in mammals |
topic | Molecular Phylogenetics and Evolution |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624410/ https://www.ncbi.nlm.nih.gov/pubmed/31334320 http://dx.doi.org/10.1016/j.dib.2019.104210 |
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