Compound Discovery and Structure-Activity Relationship Study of Neoantimycins Against Drug-Resistant Cancer Cells

Four neoantimycins H-K (1–4) with C1-keto, including the new ones (1–2), were isolated from the culture of Streptomyces conglobatus RJ8. After enzymatically converting into their respective reduced type derivatives (5–8) in vitro, the absolute structures of 1–8 were established/reconfirmed by analyz...

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Detalles Bibliográficos
Autores principales: Lin, Xiao, Zhou, Yongjun, Liu, Liyun, Zhu, Hongrui, Chen, Yeping, Wang, Shuping, Sun, Fan, Chai, Ling, Liu, Buming, Xu, Shihai, Lin, Hou-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624652/
https://www.ncbi.nlm.nih.gov/pubmed/31334224
http://dx.doi.org/10.3389/fchem.2019.00481

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