Cargando…

Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes

The inflammasome is an intracellular multi-protein complex that orchestrates the release of the pro-inflammatory cytokines IL-1β and IL-18, and a form of cell death known as pyroptosis. Tyrosine phosphorylation of the inflammasome sensors NLRP3, AIM2, NLRC4, and the adaptor protein, apoptosis-associ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mambwe, Bezaleel, Neo, Kurt, Javanmard Khameneh, Hanif, Leong, Keith Weng Kit, Colantuoni, Mariasilvia, Vacca, Maurizio, Muimo, Richmond, Mortellaro, Alessandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624653/ https://www.ncbi.nlm.nih.gov/pubmed/31333677 http://dx.doi.org/10.3389/fimmu.2019.01556

Ejemplares similares

The Inflammasome Adaptor ASC Intrinsically Limits CD4(+) T-Cell Proliferation to Help Maintain Intestinal Homeostasis
por: Javanmard Khameneh, Hanif, et al.
Publicado: (2019)

Novel perspectives on non-canonical inflammasome activation
por: Diamond, Catherine Emma, et al.
Publicado: (2015)

Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation
por: Kwak, Su-Bin, et al.
Publicado: (2018)

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes
por: Coll, Rebecca C., et al.
Publicado: (2011)

Prion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes
por: Nuvolone, Mario, et al.
Publicado: (2015)

Correction: The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes
por: Coll, Rebecca C., et al.
Publicado: (2013)

Correction: The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes
por: Coll, Rebecca C., et al.
Publicado: (2013)

NLRP10 Enhances CD4(+) T-Cell-Mediated IFNγ Response via Regulation of Dendritic Cell-Derived IL-12 Release
por: Vacca, Maurizio, et al.
Publicado: (2017)

ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation
por: Li, Shuhang, et al.
Publicado: (2021)

Gasdermins: New Therapeutic Targets in Host Defense, Inflammatory Diseases, and Cancer
por: Magnani, Laura, et al.
Publicado: (2022)

The ASC Speck and NLRP3 Inflammasome Function Are Spatially and Temporally Distinct
por: Nagar, Abhinit, et al.
Publicado: (2021)

Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides
por: Pal, Arumay, et al.
Publicado: (2019)

Calcineurin B in CD4(+) T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway
por: Mencarelli, Andrea, et al.
Publicado: (2018)

Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC
por: Zhao, Jia, et al.
Publicado: (2023)

Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis
por: Chung, I-Che, et al.
Publicado: (2016)

The Role of NLRP1, NLRP3, and AIM2 Inflammasomes in Psoriasis: Review
por: Ciążyńska, Magdalena, et al.
Publicado: (2021)

Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation
por: Darweesh, Mahmoud, et al.
Publicado: (2019)

What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research
por: Nagar, Abhinit, et al.
Publicado: (2023)

Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes
por: Sharma, Meenakshi, et al.
Publicado: (2021)

AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC
por: Hornung, Veit, et al.
Publicado: (2009)

Ethanol extract of Chrysanthemum zawadskii inhibits the NLRP3 inflammasome by suppressing ASC oligomerization in macrophages
por: Jang, Ah-Ra, et al.
Publicado: (2023)

ASC specks exacerbate α‑synuclein pathology via amplifying NLRP3 inflammasome activities
por: Zheng, Ran, et al.
Publicado: (2023)

Suppression of Glucagon-Like Peptide-1 Release by Inhibition of Intestinal NLRP3 Inflammasome Activation in Asc(–/–) and Nlrp3(–/–) Mice
por: Chen, Yu, et al.
Publicado: (2019)

Inflammasome components ASC and AIM2 modulate the acute phase of biomaterial implant-induced foreign body responses
por: Christo, Susan N., et al.
Publicado: (2016)

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation
por: Van Opdenbosch, Nina, et al.
Publicado: (2014)

Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome
por: Sun, Lingbin, et al.
Publicado: (2019)

The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC
por: Machtens, Dominik Alexander, et al.
Publicado: (2022)

TIGAR deficiency induces caspase-1-dependent trophoblasts pyroptosis through NLRP3-ASC inflammasome
por: Guo, Junjun, et al.
Publicado: (2023)

Qiqilian ameliorates vascular endothelial dysfunction by inhibiting NLRP3-ASC inflammasome activation in vivo and in vitro
por: Luo, Yuan, et al.
Publicado: (2023)

Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis
por: Diamond, Catherine E., et al.
Publicado: (2017)

Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome
por: Matyszewski, Mariusz, et al.
Publicado: (2021)

Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome
por: Birnbaum, Yochai, et al.
Publicado: (2016)

Chalcone Derivatives From Abelmoschus manihot Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization
por: Su, Jinsong, et al.
Publicado: (2022)

Dual Role of Inflammasome Adaptor ASC in Cancer
por: Protti, Maria Pia, et al.
Publicado: (2020)

ASC nanobodies to counteract the consequences of inflammasome activation
por: Adriouch, Sahil, et al.
Publicado: (2022)

Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1
por: Lichtnekert, Julia, et al.
Publicado: (2011)

Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout
por: Lee, Hye Eun, et al.
Publicado: (2016)

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
por: Xie, Min, et al.
Publicado: (2016)

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes
por: Rodrigue-Gervais, Ian Gaël, et al.
Publicado: (2018)

Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1
por: Zorman, Jernej, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6ngmi3v2mdfl4uq1m57g6r2ort