PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson’s disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to investigate the effects of parkin dysfunction on the mi...

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Detalles Bibliográficos
Autores principales: Bogetofte, Helle, Jensen, Pia, Ryding, Matias, Schmidt, Sissel I., Okarmus, Justyna, Ritter, Louise, Worm, Christina S., Hohnholt, Michaela C., Azevedo, Carla, Roybon, Laurent, Bak, Lasse K., Waagepetersen, Helle, Ryan, Brent J., Wade-Martins, Richard, Larsen, Martin R., Meyer, Morten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624735/
https://www.ncbi.nlm.nih.gov/pubmed/31333417
http://dx.doi.org/10.3389/fncel.2019.00297

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