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Rare breast and subcutaneous metastases from pancreatic neuroendocrine tumor: a case report

BACKGROUND: Neuroendocrine tumors are a group of rare neoplasms, and the pancreatic neuroendocrine tumors (PNETs) represent only 1–2% of all pancreatic malignant tumors. The most common sites of these tumors include the gastrointestinal tract, lung, adrenal gland, and thyroid gland. Moreover, the mo...

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Autores principales: Bosco, Dorotea, Perrotti, Salvatore, Spatola, Corrado, Vecchio, Giada Maria, Latino, Rosalia, Di Cataldo, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624935/
https://www.ncbi.nlm.nih.gov/pubmed/31296241
http://dx.doi.org/10.1186/s12957-019-1662-0
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author Bosco, Dorotea
Perrotti, Salvatore
Spatola, Corrado
Vecchio, Giada Maria
Latino, Rosalia
Di Cataldo, Antonio
author_facet Bosco, Dorotea
Perrotti, Salvatore
Spatola, Corrado
Vecchio, Giada Maria
Latino, Rosalia
Di Cataldo, Antonio
author_sort Bosco, Dorotea
collection PubMed
description BACKGROUND: Neuroendocrine tumors are a group of rare neoplasms, and the pancreatic neuroendocrine tumors (PNETs) represent only 1–2% of all pancreatic malignant tumors. The most common sites of these tumors include the gastrointestinal tract, lung, adrenal gland, and thyroid gland. Moreover, the most common sites of PNET metastases are the lymph nodes, liver, spleen, and bone. CASE SUMMARY: A 40-year-old woman with pT3N1 PNET underwent surgical excision of the lesion (12 cm, at the level of the pancreatic body and tail). Postsurgical treatment included chemotherapy and radiation, both of which the patient showed a good tolerance for. After a 12-month disease-free interval, however, the patient reported the development of a lesion in her left breast and a small lesion in the left posterior region of her neck. The lesions were surgically excised, and the histological findings characterized both as pancreatic neuroendocrine metastatic poorly differentiated neoplasms (G3). A re-staging CT scan showed multiple metastases in the left axillary, clavicular, and latero-cervical lymph nodes, as well as diffuse osteolytic-osteoblastic bone metastases, almost mimicking the behavior of a primitive breast tumor. CONCLUSION: This case of breast and subcutaneous metastases from PNET should prompt awareness of potential metastatic lesions in unusual locations.
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spelling pubmed-66249352019-07-23 Rare breast and subcutaneous metastases from pancreatic neuroendocrine tumor: a case report Bosco, Dorotea Perrotti, Salvatore Spatola, Corrado Vecchio, Giada Maria Latino, Rosalia Di Cataldo, Antonio World J Surg Oncol Case Report BACKGROUND: Neuroendocrine tumors are a group of rare neoplasms, and the pancreatic neuroendocrine tumors (PNETs) represent only 1–2% of all pancreatic malignant tumors. The most common sites of these tumors include the gastrointestinal tract, lung, adrenal gland, and thyroid gland. Moreover, the most common sites of PNET metastases are the lymph nodes, liver, spleen, and bone. CASE SUMMARY: A 40-year-old woman with pT3N1 PNET underwent surgical excision of the lesion (12 cm, at the level of the pancreatic body and tail). Postsurgical treatment included chemotherapy and radiation, both of which the patient showed a good tolerance for. After a 12-month disease-free interval, however, the patient reported the development of a lesion in her left breast and a small lesion in the left posterior region of her neck. The lesions were surgically excised, and the histological findings characterized both as pancreatic neuroendocrine metastatic poorly differentiated neoplasms (G3). A re-staging CT scan showed multiple metastases in the left axillary, clavicular, and latero-cervical lymph nodes, as well as diffuse osteolytic-osteoblastic bone metastases, almost mimicking the behavior of a primitive breast tumor. CONCLUSION: This case of breast and subcutaneous metastases from PNET should prompt awareness of potential metastatic lesions in unusual locations. BioMed Central 2019-07-11 /pmc/articles/PMC6624935/ /pubmed/31296241 http://dx.doi.org/10.1186/s12957-019-1662-0 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Bosco, Dorotea
Perrotti, Salvatore
Spatola, Corrado
Vecchio, Giada Maria
Latino, Rosalia
Di Cataldo, Antonio
Rare breast and subcutaneous metastases from pancreatic neuroendocrine tumor: a case report
title Rare breast and subcutaneous metastases from pancreatic neuroendocrine tumor: a case report
title_full Rare breast and subcutaneous metastases from pancreatic neuroendocrine tumor: a case report
title_fullStr Rare breast and subcutaneous metastases from pancreatic neuroendocrine tumor: a case report
title_full_unstemmed Rare breast and subcutaneous metastases from pancreatic neuroendocrine tumor: a case report
title_short Rare breast and subcutaneous metastases from pancreatic neuroendocrine tumor: a case report
title_sort rare breast and subcutaneous metastases from pancreatic neuroendocrine tumor: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624935/
https://www.ncbi.nlm.nih.gov/pubmed/31296241
http://dx.doi.org/10.1186/s12957-019-1662-0
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