GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens

Systems for CRISPR-based combinatorial perturbation of two or more genes are emerging as powerful tools for uncovering genetic interactions. However, systematic identification of these relationships is complicated by sample, reagent, and biological variability. We develop a variational Bayes approac...

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Detalles Bibliográficos
Autores principales: Zamanighomi, Mahdi, Jain, Sidharth S., Ito, Takahiro, Pal, Debjani, Daley, Timothy P., Sellers, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624979/
https://www.ncbi.nlm.nih.gov/pubmed/31300006
http://dx.doi.org/10.1186/s13059-019-1745-9

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