High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema

Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36%) of antihistamine refractory...

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Autores principales: Hofman, Zonne L. M., van West, Nikki, Hack, C. Erik, Knulst, André C., Maas, Coen, Röckmann, Heike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625121/
https://www.ncbi.nlm.nih.gov/pubmed/31338156
http://dx.doi.org/10.1186/s13601-019-0274-7
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author Hofman, Zonne L. M.
van West, Nikki
Hack, C. Erik
Knulst, André C.
Maas, Coen
Röckmann, Heike
author_facet Hofman, Zonne L. M.
van West, Nikki
Hack, C. Erik
Knulst, André C.
Maas, Coen
Röckmann, Heike
author_sort Hofman, Zonne L. M.
collection PubMed
description Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36%) of antihistamine refractory cases was observed. Forty percent of patients on antihistamine prophylaxis suffered from 1 or more angioedema attacks per month. Our findings stress the need for additional treatment options for recurrent idiopathic angioedema.
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spelling pubmed-66251212019-07-23 High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema Hofman, Zonne L. M. van West, Nikki Hack, C. Erik Knulst, André C. Maas, Coen Röckmann, Heike Clin Transl Allergy Letter to the Editor Antihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36%) of antihistamine refractory cases was observed. Forty percent of patients on antihistamine prophylaxis suffered from 1 or more angioedema attacks per month. Our findings stress the need for additional treatment options for recurrent idiopathic angioedema. BioMed Central 2019-07-12 /pmc/articles/PMC6625121/ /pubmed/31338156 http://dx.doi.org/10.1186/s13601-019-0274-7 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Hofman, Zonne L. M.
van West, Nikki
Hack, C. Erik
Knulst, André C.
Maas, Coen
Röckmann, Heike
High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
title High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
title_full High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
title_fullStr High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
title_full_unstemmed High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
title_short High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
title_sort high occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625121/
https://www.ncbi.nlm.nih.gov/pubmed/31338156
http://dx.doi.org/10.1186/s13601-019-0274-7
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