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Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases
BACKGROUND: The majority of individuals with fragile X syndrome (FXS) have intellectual disability, behavioral problems, autism, and language deficits. IQ typically declines with age in boys with the full mutation. The results of preclinical studies demonstrated that metformin, a biguanide used to t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625129/ https://www.ncbi.nlm.nih.gov/pubmed/31104364 http://dx.doi.org/10.1002/mgg3.745 |
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author | Protic, Dragana Aydin, Elber Y. Tassone, Flora Tan, Maria M. Hagerman, Randi J. Schneider, Andrea |
author_facet | Protic, Dragana Aydin, Elber Y. Tassone, Flora Tan, Maria M. Hagerman, Randi J. Schneider, Andrea |
author_sort | Protic, Dragana |
collection | PubMed |
description | BACKGROUND: The majority of individuals with fragile X syndrome (FXS) have intellectual disability, behavioral problems, autism, and language deficits. IQ typically declines with age in boys with the full mutation. The results of preclinical studies demonstrated that metformin, a biguanide used to treat type 2 diabetes, rescues multiple phenotypes of FXS in both Drosophila and mouse models. Preliminary studies of patients with FXS demonstrated improvements in behavior. METHODS: Here, we present two cases of individuals who have been treated with metformin clinically for one year. RESULTS: Both patients demonstrated significant cognitive and behavioral improvements. They also improved eating habits and normalization of their weight percentiles. CONCLUSION: Metformin may be a candidate drug for treatment of several types of symptoms in individuals with FXS. |
format | Online Article Text |
id | pubmed-6625129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66251292019-07-17 Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases Protic, Dragana Aydin, Elber Y. Tassone, Flora Tan, Maria M. Hagerman, Randi J. Schneider, Andrea Mol Genet Genomic Med Original Articles BACKGROUND: The majority of individuals with fragile X syndrome (FXS) have intellectual disability, behavioral problems, autism, and language deficits. IQ typically declines with age in boys with the full mutation. The results of preclinical studies demonstrated that metformin, a biguanide used to treat type 2 diabetes, rescues multiple phenotypes of FXS in both Drosophila and mouse models. Preliminary studies of patients with FXS demonstrated improvements in behavior. METHODS: Here, we present two cases of individuals who have been treated with metformin clinically for one year. RESULTS: Both patients demonstrated significant cognitive and behavioral improvements. They also improved eating habits and normalization of their weight percentiles. CONCLUSION: Metformin may be a candidate drug for treatment of several types of symptoms in individuals with FXS. John Wiley and Sons Inc. 2019-05-18 /pmc/articles/PMC6625129/ /pubmed/31104364 http://dx.doi.org/10.1002/mgg3.745 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Protic, Dragana Aydin, Elber Y. Tassone, Flora Tan, Maria M. Hagerman, Randi J. Schneider, Andrea Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases |
title | Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases |
title_full | Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases |
title_fullStr | Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases |
title_full_unstemmed | Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases |
title_short | Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases |
title_sort | cognitive and behavioral improvement in adults with fragile x syndrome treated with metformin‐two cases |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625129/ https://www.ncbi.nlm.nih.gov/pubmed/31104364 http://dx.doi.org/10.1002/mgg3.745 |
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