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Implementation of “Treat‐all” at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey

INTRODUCTION: Since 2015, the World Health Organization (WHO) has recommended that all people living with HIV (PLHIV) initiate antiretroviral treatment (ART), irrespective of CD4+ count or clinical stage. National adoption of universal treatment has accelerated since WHO's 2015 “Treat All” reco...

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Autores principales: Brazier, Ellen, Maruri, Fernanda, Duda, Stephany N, Tymejczyk, Olga, Wester, C William, Somi, Geoffrey, Ross, Jeremy, Freeman, Aimee, Cornell, Morna, Poda, Armel, Musick, Beverly S, Zhang, Fujie, Althoff, Keri N, Mugglin, Catrina, Kimmel, April D, Yotebieng, Marcel, Nash, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625339/
https://www.ncbi.nlm.nih.gov/pubmed/31623428
http://dx.doi.org/10.1002/jia2.25331
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author Brazier, Ellen
Maruri, Fernanda
Duda, Stephany N
Tymejczyk, Olga
Wester, C William
Somi, Geoffrey
Ross, Jeremy
Freeman, Aimee
Cornell, Morna
Poda, Armel
Musick, Beverly S
Zhang, Fujie
Althoff, Keri N
Mugglin, Catrina
Kimmel, April D
Yotebieng, Marcel
Nash, Denis
author_facet Brazier, Ellen
Maruri, Fernanda
Duda, Stephany N
Tymejczyk, Olga
Wester, C William
Somi, Geoffrey
Ross, Jeremy
Freeman, Aimee
Cornell, Morna
Poda, Armel
Musick, Beverly S
Zhang, Fujie
Althoff, Keri N
Mugglin, Catrina
Kimmel, April D
Yotebieng, Marcel
Nash, Denis
author_sort Brazier, Ellen
collection PubMed
description INTRODUCTION: Since 2015, the World Health Organization (WHO) has recommended that all people living with HIV (PLHIV) initiate antiretroviral treatment (ART), irrespective of CD4+ count or clinical stage. National adoption of universal treatment has accelerated since WHO's 2015 “Treat All” recommendation; however, little is known about the translation of this guidance into practice. This study aimed to assess the status of Treat All implementation across regions, countries, and levels of the health care delivery system. METHODS: Between June and December 2017, 201/221 (91%) adult HIV treatment sites that participate in the global IeDEA research consortium completed a survey on capacity and practices related to HIV care. Located in 41 countries across seven geographic regions, sites provided information on the status and timing of site‐level introduction of Treat All, as well as site‐level practices related to ART initiation. RESULTS: Almost all sites (93%) reported that they had begun implementing Treat All, and there were no statistically significant differences in site‐level Treat All introduction by health facility type, urban/rural location, sector (public/private) or country income level. The median time between national policy adoption and site‐level introduction was one month. In countries where Treat All was not yet adopted in national guidelines, 69% of sites reported initiating all patients on ART, regardless of clinical criteria, and these sites had been implementing Treat All for a median period of seven months at the time of the survey. The majority of sites (77%) reported typically initiating patients on ART within 14 days of confirming diagnosis, with 60% to 62% of sites implementing Treat All in East, Southern and West Africa reporting same‐day ART initiation for most patients. CONCLUSIONS: By mid‐ to late‐2017, the Treat All strategy was the standard of care at almost all IeDEA sites, including rural, primary‐level health facilities in low‐resource settings. While further assessments of site‐level capacity to provide high‐quality HIV care under Treat All and to support sustained viral suppression after ART initiation are needed, the widespread introduction of Treat All at the service delivery level is a critical step towards global targets for ending the HIV epidemic as a public health threat.
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spelling pubmed-66253392019-07-16 Implementation of “Treat‐all” at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey Brazier, Ellen Maruri, Fernanda Duda, Stephany N Tymejczyk, Olga Wester, C William Somi, Geoffrey Ross, Jeremy Freeman, Aimee Cornell, Morna Poda, Armel Musick, Beverly S Zhang, Fujie Althoff, Keri N Mugglin, Catrina Kimmel, April D Yotebieng, Marcel Nash, Denis J Int AIDS Soc Research Articles INTRODUCTION: Since 2015, the World Health Organization (WHO) has recommended that all people living with HIV (PLHIV) initiate antiretroviral treatment (ART), irrespective of CD4+ count or clinical stage. National adoption of universal treatment has accelerated since WHO's 2015 “Treat All” recommendation; however, little is known about the translation of this guidance into practice. This study aimed to assess the status of Treat All implementation across regions, countries, and levels of the health care delivery system. METHODS: Between June and December 2017, 201/221 (91%) adult HIV treatment sites that participate in the global IeDEA research consortium completed a survey on capacity and practices related to HIV care. Located in 41 countries across seven geographic regions, sites provided information on the status and timing of site‐level introduction of Treat All, as well as site‐level practices related to ART initiation. RESULTS: Almost all sites (93%) reported that they had begun implementing Treat All, and there were no statistically significant differences in site‐level Treat All introduction by health facility type, urban/rural location, sector (public/private) or country income level. The median time between national policy adoption and site‐level introduction was one month. In countries where Treat All was not yet adopted in national guidelines, 69% of sites reported initiating all patients on ART, regardless of clinical criteria, and these sites had been implementing Treat All for a median period of seven months at the time of the survey. The majority of sites (77%) reported typically initiating patients on ART within 14 days of confirming diagnosis, with 60% to 62% of sites implementing Treat All in East, Southern and West Africa reporting same‐day ART initiation for most patients. CONCLUSIONS: By mid‐ to late‐2017, the Treat All strategy was the standard of care at almost all IeDEA sites, including rural, primary‐level health facilities in low‐resource settings. While further assessments of site‐level capacity to provide high‐quality HIV care under Treat All and to support sustained viral suppression after ART initiation are needed, the widespread introduction of Treat All at the service delivery level is a critical step towards global targets for ending the HIV epidemic as a public health threat. John Wiley and Sons Inc. 2019-07-12 /pmc/articles/PMC6625339/ /pubmed/31623428 http://dx.doi.org/10.1002/jia2.25331 Text en © 2019 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Brazier, Ellen
Maruri, Fernanda
Duda, Stephany N
Tymejczyk, Olga
Wester, C William
Somi, Geoffrey
Ross, Jeremy
Freeman, Aimee
Cornell, Morna
Poda, Armel
Musick, Beverly S
Zhang, Fujie
Althoff, Keri N
Mugglin, Catrina
Kimmel, April D
Yotebieng, Marcel
Nash, Denis
Implementation of “Treat‐all” at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey
title Implementation of “Treat‐all” at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey
title_full Implementation of “Treat‐all” at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey
title_fullStr Implementation of “Treat‐all” at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey
title_full_unstemmed Implementation of “Treat‐all” at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey
title_short Implementation of “Treat‐all” at adult HIV care and treatment sites in the Global IeDEA Consortium: results from the Site Assessment Survey
title_sort implementation of “treat‐all” at adult hiv care and treatment sites in the global iedea consortium: results from the site assessment survey
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625339/
https://www.ncbi.nlm.nih.gov/pubmed/31623428
http://dx.doi.org/10.1002/jia2.25331
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