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Evidence for SIRT1 Mediated HMGB1 Release From Kidney Cells in the Early Stages of Hemorrhagic Shock
BACKGROUND: This study is to explore the effect of SIRT1 deacetylating inactivation on organ-derived high mobility group box 1 (HMGB1) during the development of severe hemorrhagic shock (HS). METHODS: Hemorrhagic shock model was reproduced in rats by blood shedding and mimicked in HK-2 cells by hypo...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625367/ https://www.ncbi.nlm.nih.gov/pubmed/31333497 http://dx.doi.org/10.3389/fphys.2019.00854 |