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Resistance to Stress Can Be Experimentally Dissociated From Longevity

On the basis of multiple experiments demonstrating that high resistance to stress is associated with long lifespan, it has been proposed that stress resistance is a key determinant of longevity. However, the extent to which high resistance to stress is necessary or sufficient for long life is curren...

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Autores principales: Dues, Dylan J, Andrews, Emily K, Senchuk, Megan M, Van Raamsdonk, Jeremy M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625593/
https://www.ncbi.nlm.nih.gov/pubmed/30247515
http://dx.doi.org/10.1093/gerona/gly213
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author Dues, Dylan J
Andrews, Emily K
Senchuk, Megan M
Van Raamsdonk, Jeremy M
author_facet Dues, Dylan J
Andrews, Emily K
Senchuk, Megan M
Van Raamsdonk, Jeremy M
author_sort Dues, Dylan J
collection PubMed
description On the basis of multiple experiments demonstrating that high resistance to stress is associated with long lifespan, it has been proposed that stress resistance is a key determinant of longevity. However, the extent to which high resistance to stress is necessary or sufficient for long life is currently unclear. In this work, we use a genetic approach to disrupt different stress response pathways and examine the resulting effect on the longevity of the long-lived insulin-like growth factor 1 (IGF1) receptor mutant daf-2. Although mutation of the heat shock factor gene hsf-1, deletion of sod genes, deletion of the p38 MAPK kinase gene pmk-1, or deletion of the transcription factor gene egl-27 all resulted in decreased resistance to at least one form of stress and decreased lifespan, the magnitude of change in stress resistance did not correspond to the magnitude of change in lifespan. In addition, we found that deletion of the glycerol-3-phosphate dehydrogenase genes gpdh-1 and gpdh-2 or deletion of the DAF-16 cofactor gene nhl-1 also results in decreased resistance to at least one form of stress but increases lifespan. Overall, our results suggest that while increased stress resistance is associated with longevity, stress resistance, and lifespan can be experimentally dissociated.
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spelling pubmed-66255932019-07-17 Resistance to Stress Can Be Experimentally Dissociated From Longevity Dues, Dylan J Andrews, Emily K Senchuk, Megan M Van Raamsdonk, Jeremy M J Gerontol A Biol Sci Med Sci The Journal of Gerontology: Biological Sciences On the basis of multiple experiments demonstrating that high resistance to stress is associated with long lifespan, it has been proposed that stress resistance is a key determinant of longevity. However, the extent to which high resistance to stress is necessary or sufficient for long life is currently unclear. In this work, we use a genetic approach to disrupt different stress response pathways and examine the resulting effect on the longevity of the long-lived insulin-like growth factor 1 (IGF1) receptor mutant daf-2. Although mutation of the heat shock factor gene hsf-1, deletion of sod genes, deletion of the p38 MAPK kinase gene pmk-1, or deletion of the transcription factor gene egl-27 all resulted in decreased resistance to at least one form of stress and decreased lifespan, the magnitude of change in stress resistance did not correspond to the magnitude of change in lifespan. In addition, we found that deletion of the glycerol-3-phosphate dehydrogenase genes gpdh-1 and gpdh-2 or deletion of the DAF-16 cofactor gene nhl-1 also results in decreased resistance to at least one form of stress but increases lifespan. Overall, our results suggest that while increased stress resistance is associated with longevity, stress resistance, and lifespan can be experimentally dissociated. Oxford University Press 2019-07 2018-09-21 /pmc/articles/PMC6625593/ /pubmed/30247515 http://dx.doi.org/10.1093/gerona/gly213 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle The Journal of Gerontology: Biological Sciences
Dues, Dylan J
Andrews, Emily K
Senchuk, Megan M
Van Raamsdonk, Jeremy M
Resistance to Stress Can Be Experimentally Dissociated From Longevity
title Resistance to Stress Can Be Experimentally Dissociated From Longevity
title_full Resistance to Stress Can Be Experimentally Dissociated From Longevity
title_fullStr Resistance to Stress Can Be Experimentally Dissociated From Longevity
title_full_unstemmed Resistance to Stress Can Be Experimentally Dissociated From Longevity
title_short Resistance to Stress Can Be Experimentally Dissociated From Longevity
title_sort resistance to stress can be experimentally dissociated from longevity
topic The Journal of Gerontology: Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625593/
https://www.ncbi.nlm.nih.gov/pubmed/30247515
http://dx.doi.org/10.1093/gerona/gly213
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