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XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease

The unfolded protein response (UPR) is a conserved cellular response to the accumulation of proteinaceous material in endoplasmic reticulum (ER), active both in health and disease to alleviate cellular stress and improve protein folding. Multiple epiphyseal dysplasia (EDM5) is a genetic skeletal con...

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Detalles Bibliográficos
Autores principales:	Piróg, Katarzyna A., Dennis, Ella P., Hartley, Claire L., Jackson, Robert M., Soul, Jamie, Schwartz, Jean-Marc, Bateman, John F., Boot-Handford, Raymond P., Briggs, Michael D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625722/ https://www.ncbi.nlm.nih.gov/pubmed/31260448 http://dx.doi.org/10.1371/journal.pgen.1008215

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