MST1R Kinase Accelerates Pancreatic Cancer Progression Via Effects on both Epithelial Cells and Macrophages

The MST1R (RON) kinase is overexpressed in >80% of human pancreatic cancers, but its role in pancreatic carcinogenesis is unknown. In this study, we examined the relevance of Mst1r kinase to Kras driven pancreatic carcinogenesis using genetically engineered mouse models. In the setting of mutant...

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Detalles Bibliográficos
Autores principales: Babicky, Michele L., Harper, Megan M., Chakedis, Jeffery, Cazes, Alex, Mose, Evangeline S., Jaquish, Dawn V., French, Randall P., Childers, Betzaira, Alakus, Hakan, Schmid, Michael C., Foubert, Phillippe, Miyamoto, Jaclyn, Holman, Patrick J., Walterscheid, Zakkary J., Tang, Chih-Min, Varki, Nissi, Sicklick, Jason K., Messer, Karen, Varner, Judith A., Waltz, Susan E., Lowy, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625868/
https://www.ncbi.nlm.nih.gov/pubmed/30967626
http://dx.doi.org/10.1038/s41388-019-0811-9

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