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Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation

The role of brain somatic mutations in Alzheimer’s disease (AD) is not well understood. Here, we perform deep whole-exome sequencing (average read depth 584×) in 111 postmortem hippocampal formation and matched blood samples from 52 patients with AD and 11 individuals not affected by AD. The number...

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Detalles Bibliográficos
Autores principales:	Park, Jun Sung, Lee, Junehawk, Jung, Eun Sun, Kim, Myeong-Heui, Kim, Il Bin, Son, Hyeonju, Kim, Sangwoo, Kim, Sanghyeon, Park, Young Mok, Mook-Jung, Inhee, Yu, Seok Jong, Lee, Jeong Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626023/ https://www.ncbi.nlm.nih.gov/pubmed/31300647 http://dx.doi.org/10.1038/s41467-019-11000-7

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