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The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X
DEAD-box helicases (DDXs) regulate RNA processing and metabolism by unwinding short double-stranded (ds) RNAs. Sharing a helicase core composed of two RecA-like domains (D1D2), DDXs function in an ATP-dependent, non-processive manner. As an attractive target for cancer and AIDS treatment, DDX3X and...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626043/ https://www.ncbi.nlm.nih.gov/pubmed/31300642 http://dx.doi.org/10.1038/s41467-019-11083-2 |