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Biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy
Regenerative medicine is a new and promising medical method aiming at treating patients with defective or dysfunctional tissues by maintaining or enhancing the biological activity of cells. The development of biomaterial-based technologies, such as cell scaffolds and carriers for drug delivery syste...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Society for Regenerative Medicine
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626072/ https://www.ncbi.nlm.nih.gov/pubmed/31338391 http://dx.doi.org/10.1016/j.reth.2019.06.007 |
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author | Jo, Jun-ichiro Gao, Jian-Qing Tabata, Yasuhiko |
author_facet | Jo, Jun-ichiro Gao, Jian-Qing Tabata, Yasuhiko |
author_sort | Jo, Jun-ichiro |
collection | PubMed |
description | Regenerative medicine is a new and promising medical method aiming at treating patients with defective or dysfunctional tissues by maintaining or enhancing the biological activity of cells. The development of biomaterial-based technologies, such as cell scaffolds and carriers for drug delivery system, are highly required to promote the regenerative research and regenerative therapy. Nucleic acids are one of the most feasible factors to efficiently modify the biological activity of cells. The effective and stable delivery of nucleic acids into cells is highly required to succeed in the modification. Biomaterials-based non-viral carriers or biological carriers, like exosomes, play an important role in the efficient delivery of nucleic acids. This review introduces the examples of regenerative research and regenerative therapy based on the delivery of nucleic acids with biomaterials technologies and emphasizes their importance to accomplish regenerative medicine. |
format | Online Article Text |
id | pubmed-6626072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Japanese Society for Regenerative Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-66260722019-07-23 Biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy Jo, Jun-ichiro Gao, Jian-Qing Tabata, Yasuhiko Regen Ther Review Article Regenerative medicine is a new and promising medical method aiming at treating patients with defective or dysfunctional tissues by maintaining or enhancing the biological activity of cells. The development of biomaterial-based technologies, such as cell scaffolds and carriers for drug delivery system, are highly required to promote the regenerative research and regenerative therapy. Nucleic acids are one of the most feasible factors to efficiently modify the biological activity of cells. The effective and stable delivery of nucleic acids into cells is highly required to succeed in the modification. Biomaterials-based non-viral carriers or biological carriers, like exosomes, play an important role in the efficient delivery of nucleic acids. This review introduces the examples of regenerative research and regenerative therapy based on the delivery of nucleic acids with biomaterials technologies and emphasizes their importance to accomplish regenerative medicine. Japanese Society for Regenerative Medicine 2019-07-11 /pmc/articles/PMC6626072/ /pubmed/31338391 http://dx.doi.org/10.1016/j.reth.2019.06.007 Text en © 2019 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Jo, Jun-ichiro Gao, Jian-Qing Tabata, Yasuhiko Biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy |
title | Biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy |
title_full | Biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy |
title_fullStr | Biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy |
title_full_unstemmed | Biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy |
title_short | Biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy |
title_sort | biomaterial-based delivery systems of nucleic acid for regenerative research and regenerative therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626072/ https://www.ncbi.nlm.nih.gov/pubmed/31338391 http://dx.doi.org/10.1016/j.reth.2019.06.007 |
work_keys_str_mv | AT jojunichiro biomaterialbaseddeliverysystemsofnucleicacidforregenerativeresearchandregenerativetherapy AT gaojianqing biomaterialbaseddeliverysystemsofnucleicacidforregenerativeresearchandregenerativetherapy AT tabatayasuhiko biomaterialbaseddeliverysystemsofnucleicacidforregenerativeresearchandregenerativetherapy |