Cargando…
Increasing the specificity of CRISPR systems with engineered RNA secondary structures
CRISPR systems have been broadly adopted for basic science, biotechnology, and gene and cell therapy. In some cases, these bacterial nucleases have demonstrated off-target activity. This creates a potential hazard for therapeutic applications and could confound results in biological research. Theref...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626619/ https://www.ncbi.nlm.nih.gov/pubmed/30988504 http://dx.doi.org/10.1038/s41587-019-0095-1 |