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First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran

BACKGROUND AND PURPOSE: Herein, we report the first case of fungal keratitis due to Aspergillus minisclerotigenes in a 68-year-old rural woman admitted to the Ophthalmology Center of Khatam-Al-Anbia Hospital in Mashhad, northeast of Iran. CASE REPORT: The patient presented with severe pain, burning,...

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Autores principales: Karimizadeh Esfahani, Mahmoud, Eslampoor, Alireza, Dolatabadi, Somayeh, Najafzadeh, Mohammad J., Houbraken, Jos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Medical Mycology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626709/
https://www.ncbi.nlm.nih.gov/pubmed/31321339
http://dx.doi.org/10.18502/cmm.5.2.1162
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author Karimizadeh Esfahani, Mahmoud
Eslampoor, Alireza
Dolatabadi, Somayeh
Najafzadeh, Mohammad J.
Houbraken, Jos
author_facet Karimizadeh Esfahani, Mahmoud
Eslampoor, Alireza
Dolatabadi, Somayeh
Najafzadeh, Mohammad J.
Houbraken, Jos
author_sort Karimizadeh Esfahani, Mahmoud
collection PubMed
description BACKGROUND AND PURPOSE: Herein, we report the first case of fungal keratitis due to Aspergillus minisclerotigenes in a 68-year-old rural woman admitted to the Ophthalmology Center of Khatam-Al-Anbia Hospital in Mashhad, northeast of Iran. CASE REPORT: The patient presented with severe pain, burning, foreign body sensation, and reduced vision in her right eye. She had long-term uncontrolled diabetes and was not able to close her eye due to an anatomical problem with the eyelid. The cornea smear sample was cultured, and the fungus was initially identified as Aspergillus flavus. The isolated strain was further identified by sequencing a part of the calmodulin gene as A. minisclerotigenes. The patient did not respond to any antifungal treatments (e.g., amphotericin B and voriconazole drops, and fluconazole 300 mg/day); therefore, she was eventually subjected to corneal transplantation surgery. CONCLUSION: Fungal keratitis can be caused by the less common species. The reliable identification of the causative agents can be accomplished by the implementation of molecular methods.
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spelling pubmed-66267092019-07-18 First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran Karimizadeh Esfahani, Mahmoud Eslampoor, Alireza Dolatabadi, Somayeh Najafzadeh, Mohammad J. Houbraken, Jos Curr Med Mycol Case Report BACKGROUND AND PURPOSE: Herein, we report the first case of fungal keratitis due to Aspergillus minisclerotigenes in a 68-year-old rural woman admitted to the Ophthalmology Center of Khatam-Al-Anbia Hospital in Mashhad, northeast of Iran. CASE REPORT: The patient presented with severe pain, burning, foreign body sensation, and reduced vision in her right eye. She had long-term uncontrolled diabetes and was not able to close her eye due to an anatomical problem with the eyelid. The cornea smear sample was cultured, and the fungus was initially identified as Aspergillus flavus. The isolated strain was further identified by sequencing a part of the calmodulin gene as A. minisclerotigenes. The patient did not respond to any antifungal treatments (e.g., amphotericin B and voriconazole drops, and fluconazole 300 mg/day); therefore, she was eventually subjected to corneal transplantation surgery. CONCLUSION: Fungal keratitis can be caused by the less common species. The reliable identification of the causative agents can be accomplished by the implementation of molecular methods. Iranian Society of Medical Mycology 2019-06 /pmc/articles/PMC6626709/ /pubmed/31321339 http://dx.doi.org/10.18502/cmm.5.2.1162 Text en © 2019, Published by Mazandaran University of Medical Sciences on behalf of Iranian Society of Medical Mycology and Invasive Fungi Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Karimizadeh Esfahani, Mahmoud
Eslampoor, Alireza
Dolatabadi, Somayeh
Najafzadeh, Mohammad J.
Houbraken, Jos
First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran
title First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran
title_full First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran
title_fullStr First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran
title_full_unstemmed First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran
title_short First case of fungal keratitis due to Aspergillus minisclerotigenes in Iran
title_sort first case of fungal keratitis due to aspergillus minisclerotigenes in iran
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626709/
https://www.ncbi.nlm.nih.gov/pubmed/31321339
http://dx.doi.org/10.18502/cmm.5.2.1162
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