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Genome-wide copy number variant data for inflammatory bowel disease in a caucasian population

Genome-wide copy-number association studies offer new opportunities to identify the mechanisms underlying complex diseases, including chronic inflammatory, psychiatric disorders and others. We have used genotyping microarrays to analyse the copy-number variants (CNVs) from 243 Caucasian individuals...

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Autores principales: Frenkel, Svetlana, Bernstein, Charles N., Jin, Yong Won, Sargent, Michael, Kuang, Qin, Jiang, Wenxin, Wei, John, Thiruvahindrapuram, Bhooma, Scherer, Stephen W., Hu, Pingzhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626884/
https://www.ncbi.nlm.nih.gov/pubmed/31338399
http://dx.doi.org/10.1016/j.dib.2019.104203
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author Frenkel, Svetlana
Bernstein, Charles N.
Jin, Yong Won
Sargent, Michael
Kuang, Qin
Jiang, Wenxin
Wei, John
Thiruvahindrapuram, Bhooma
Scherer, Stephen W.
Hu, Pingzhao
author_facet Frenkel, Svetlana
Bernstein, Charles N.
Jin, Yong Won
Sargent, Michael
Kuang, Qin
Jiang, Wenxin
Wei, John
Thiruvahindrapuram, Bhooma
Scherer, Stephen W.
Hu, Pingzhao
author_sort Frenkel, Svetlana
collection PubMed
description Genome-wide copy-number association studies offer new opportunities to identify the mechanisms underlying complex diseases, including chronic inflammatory, psychiatric disorders and others. We have used genotyping microarrays to analyse the copy-number variants (CNVs) from 243 Caucasian individuals with Inflammatory Bowel Disease (IBD). The CNV data was obtained by using multiple quality control measures and merging the results of three different CNV detection algorithms: PennCNV, iPattern, and QuantiSNP. The final dataset contains 4,402 CNVs detected by two or three algorithms independently with high confidence. This paper provides a detailed description of the data generation and quality control steps. For further interpretation of the data presented in this article, please see the research article entitled ‘Copy number variation-based gene set analysis reveals cytokine signalling pathways associated with psychiatric comorbidity in patients with inflammatory bowel disease’.
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spelling pubmed-66268842019-07-23 Genome-wide copy number variant data for inflammatory bowel disease in a caucasian population Frenkel, Svetlana Bernstein, Charles N. Jin, Yong Won Sargent, Michael Kuang, Qin Jiang, Wenxin Wei, John Thiruvahindrapuram, Bhooma Scherer, Stephen W. Hu, Pingzhao Data Brief Biochemistry, Genetics and Molecular Biology Genome-wide copy-number association studies offer new opportunities to identify the mechanisms underlying complex diseases, including chronic inflammatory, psychiatric disorders and others. We have used genotyping microarrays to analyse the copy-number variants (CNVs) from 243 Caucasian individuals with Inflammatory Bowel Disease (IBD). The CNV data was obtained by using multiple quality control measures and merging the results of three different CNV detection algorithms: PennCNV, iPattern, and QuantiSNP. The final dataset contains 4,402 CNVs detected by two or three algorithms independently with high confidence. This paper provides a detailed description of the data generation and quality control steps. For further interpretation of the data presented in this article, please see the research article entitled ‘Copy number variation-based gene set analysis reveals cytokine signalling pathways associated with psychiatric comorbidity in patients with inflammatory bowel disease’. Elsevier 2019-07-02 /pmc/articles/PMC6626884/ /pubmed/31338399 http://dx.doi.org/10.1016/j.dib.2019.104203 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Biochemistry, Genetics and Molecular Biology
Frenkel, Svetlana
Bernstein, Charles N.
Jin, Yong Won
Sargent, Michael
Kuang, Qin
Jiang, Wenxin
Wei, John
Thiruvahindrapuram, Bhooma
Scherer, Stephen W.
Hu, Pingzhao
Genome-wide copy number variant data for inflammatory bowel disease in a caucasian population
title Genome-wide copy number variant data for inflammatory bowel disease in a caucasian population
title_full Genome-wide copy number variant data for inflammatory bowel disease in a caucasian population
title_fullStr Genome-wide copy number variant data for inflammatory bowel disease in a caucasian population
title_full_unstemmed Genome-wide copy number variant data for inflammatory bowel disease in a caucasian population
title_short Genome-wide copy number variant data for inflammatory bowel disease in a caucasian population
title_sort genome-wide copy number variant data for inflammatory bowel disease in a caucasian population
topic Biochemistry, Genetics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626884/
https://www.ncbi.nlm.nih.gov/pubmed/31338399
http://dx.doi.org/10.1016/j.dib.2019.104203
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