Short-term pharmacological activation of Nrf2 ameliorates vascular dysfunction in aged rats and in pathological human vasculature. A potential target for therapeutic intervention

Oxidative stress contributes to endothelial dysfunction, a key step in cardiovascular disease development. Ageing-related vascular dysfunction involves defective antioxidant response. Nuclear factor erythroid 2-like-2 (Nrf2), orchestrates cellular response to oxidative stress. We evaluated the impac...

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Detalles Bibliográficos
Autores principales: Angulo, Javier, El Assar, Mariam, Sevilleja-Ortiz, Alejandro, Fernández, Argentina, Sánchez-Ferrer, Alberto, Romero-Otero, Javier, Martínez-Salamanca, Juan I., La Fuente, José M., Rodríguez-Mañas, Leocadio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626891/
https://www.ncbi.nlm.nih.gov/pubmed/31302408
http://dx.doi.org/10.1016/j.redox.2019.101271

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