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Identification of a variant associated with early‐onset diabetes in the intron of the insulin gene with exome sequencing
Whole‐exome sequencing is a new technology. We used it to explore the gene responsible for early‐onset diabetes as a result of impaired insulin secretion in a family. In the INS gene, we identified the heterozygous c.188‐31G>A mutation in the proband – a 43‐year‐old woman. The mutation was also i...
Autores principales: | Matsuno, Shohei, Furuta, Hiroto, Kosaka, Kitaro, Doi, Asako, Yorifuji, Tohru, Fukuda, Takuya, Senmaru, Takafumi, Uraki, Shinsuke, Matsutani, Norihiko, Furuta, Machi, Mishima, Hiroyuki, Iwakura, Hiroshi, Nishi, Masahiro, Yoshiura, Kohichiro, Fukui, Michiaki, Akamizu, Takashi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626945/ https://www.ncbi.nlm.nih.gov/pubmed/30414308 http://dx.doi.org/10.1111/jdi.12974 |
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