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Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice
Given the established roles of glucose‐dependent insulinotropic polypeptide (GIP) in promoting fat storage and bone formation, we assessed the contribution of GIP to obesity and osteopenia in ovariectomized mice with a gene encoding green fluorescent protein (GFP) inserted into the GIP locus, in whi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626948/ https://www.ncbi.nlm.nih.gov/pubmed/30451382 http://dx.doi.org/10.1111/jdi.12978 |
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author | Shimazu‐Kuwahara, Satoko Kanemaru, Yoshinori Harada, Norio Ikeguchi, Eri Ueda, Yohei Yamane, Shunsuke Murata, Yuki Yasoda, Akihiro Kieffer, Timothy J Inagaki, Nobuya |
author_facet | Shimazu‐Kuwahara, Satoko Kanemaru, Yoshinori Harada, Norio Ikeguchi, Eri Ueda, Yohei Yamane, Shunsuke Murata, Yuki Yasoda, Akihiro Kieffer, Timothy J Inagaki, Nobuya |
author_sort | Shimazu‐Kuwahara, Satoko |
collection | PubMed |
description | Given the established roles of glucose‐dependent insulinotropic polypeptide (GIP) in promoting fat storage and bone formation, we assessed the contribution of GIP to obesity and osteopenia in ovariectomized mice with a gene encoding green fluorescent protein (GFP) inserted into the GIP locus, in which GIP was either reduced (GIP(gfp/+)) or absent (GIP(gfp/gfp)). In GIP(gfp/gfp) mice, weight gain, subcutaneous and visceral fat mass were reduced, and glucose intolerance was improved compared with wild‐type mice with the same magnitude of insulin responses. Cancellous bone mineral density and bone cortical thickness were reduced in GIP(gfp/gfp) mice compared with wild‐type mice. In GIP(gfp/+) mice, weight gain, glucose intolerance and cancellous bone mineral density were not different from that of wild‐type mice. These results indicate that the total elimination of GIP ameliorates weight gain and adiposity in ovariectomized mice, but it enhances osteopenia, particularly in cancellous bone by partly suppressing bone formation. |
format | Online Article Text |
id | pubmed-6626948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66269482019-07-17 Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice Shimazu‐Kuwahara, Satoko Kanemaru, Yoshinori Harada, Norio Ikeguchi, Eri Ueda, Yohei Yamane, Shunsuke Murata, Yuki Yasoda, Akihiro Kieffer, Timothy J Inagaki, Nobuya J Diabetes Investig Articles Given the established roles of glucose‐dependent insulinotropic polypeptide (GIP) in promoting fat storage and bone formation, we assessed the contribution of GIP to obesity and osteopenia in ovariectomized mice with a gene encoding green fluorescent protein (GFP) inserted into the GIP locus, in which GIP was either reduced (GIP(gfp/+)) or absent (GIP(gfp/gfp)). In GIP(gfp/gfp) mice, weight gain, subcutaneous and visceral fat mass were reduced, and glucose intolerance was improved compared with wild‐type mice with the same magnitude of insulin responses. Cancellous bone mineral density and bone cortical thickness were reduced in GIP(gfp/gfp) mice compared with wild‐type mice. In GIP(gfp/+) mice, weight gain, glucose intolerance and cancellous bone mineral density were not different from that of wild‐type mice. These results indicate that the total elimination of GIP ameliorates weight gain and adiposity in ovariectomized mice, but it enhances osteopenia, particularly in cancellous bone by partly suppressing bone formation. John Wiley and Sons Inc. 2018-12-27 2019-07 /pmc/articles/PMC6626948/ /pubmed/30451382 http://dx.doi.org/10.1111/jdi.12978 Text en © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Articles Shimazu‐Kuwahara, Satoko Kanemaru, Yoshinori Harada, Norio Ikeguchi, Eri Ueda, Yohei Yamane, Shunsuke Murata, Yuki Yasoda, Akihiro Kieffer, Timothy J Inagaki, Nobuya Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice |
title | Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice |
title_full | Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice |
title_fullStr | Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice |
title_full_unstemmed | Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice |
title_short | Glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice |
title_sort | glucose‐dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626948/ https://www.ncbi.nlm.nih.gov/pubmed/30451382 http://dx.doi.org/10.1111/jdi.12978 |
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