Melanoma Progression Inhibits Pluripotency and Differentiation of Melanoma-Derived iPSCs Produces Cells with Neural-like Mixed Dysplastic Phenotype

Melanomas are known to exhibit phenotypic plasticity. However, the role cellular plasticity plays in melanoma tumor progression and drug resistance is not fully understood. Here, we used reprogramming of melanocytes and melanoma cells to induced pluripotent stem cell (iPSCs) to investigate the relat...

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Detalles Bibliográficos
Autores principales: Castro-Pérez, Edgardo, Rodríguez, Carlos I., Mikheil, Dareen, Siddique, Shakir, McCarthy, Alexandra, Newton, Michael A., Setaluri, Vijayasaradhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627006/
https://www.ncbi.nlm.nih.gov/pubmed/31231022
http://dx.doi.org/10.1016/j.stemcr.2019.05.018

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