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Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis

Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development, emerging evidence indicates that tumor microenvironment-mediated changes in glycosylation play a crucial functional role in tumor progression and metastasis. Hypoxia and inflammatory events regulate protein gly...

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Detalles Bibliográficos
Autores principales: Brown Chandler, Kevin, E. Costello, Catherine, Rahimi, Nader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627046/
https://www.ncbi.nlm.nih.gov/pubmed/31195728
http://dx.doi.org/10.3390/cells8060544
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author Brown Chandler, Kevin
E. Costello, Catherine
Rahimi, Nader
author_facet Brown Chandler, Kevin
E. Costello, Catherine
Rahimi, Nader
author_sort Brown Chandler, Kevin
collection PubMed
description Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development, emerging evidence indicates that tumor microenvironment-mediated changes in glycosylation play a crucial functional role in tumor progression and metastasis. Hypoxia and inflammatory events regulate protein glycosylation in tumor cells and associated stromal cells in the tumor microenvironment, which facilitates tumor progression and also modulates a patient’s response to anti-cancer therapeutics. In this review, we highlight the impact of altered glycosylation on angiogenic signaling and endothelial cell adhesion, and the critical consequences of these changes in tumor behavior.
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spelling pubmed-66270462019-07-19 Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis Brown Chandler, Kevin E. Costello, Catherine Rahimi, Nader Cells Review Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development, emerging evidence indicates that tumor microenvironment-mediated changes in glycosylation play a crucial functional role in tumor progression and metastasis. Hypoxia and inflammatory events regulate protein glycosylation in tumor cells and associated stromal cells in the tumor microenvironment, which facilitates tumor progression and also modulates a patient’s response to anti-cancer therapeutics. In this review, we highlight the impact of altered glycosylation on angiogenic signaling and endothelial cell adhesion, and the critical consequences of these changes in tumor behavior. MDPI 2019-06-05 /pmc/articles/PMC6627046/ /pubmed/31195728 http://dx.doi.org/10.3390/cells8060544 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Brown Chandler, Kevin
E. Costello, Catherine
Rahimi, Nader
Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
title Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
title_full Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
title_fullStr Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
title_full_unstemmed Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
title_short Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis
title_sort glycosylation in the tumor microenvironment: implications for tumor angiogenesis and metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627046/
https://www.ncbi.nlm.nih.gov/pubmed/31195728
http://dx.doi.org/10.3390/cells8060544
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