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Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making?
Inflammatory bowel disease (IBD) is a heterogeneous disorder in terms of age at onset, clinical phenotypes, severity, disease course, and response to therapy. This underlines the need for predictive and precision medicine that can optimize diagnosis and disease management, provide more cost-effectiv...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627070/ https://www.ncbi.nlm.nih.gov/pubmed/31167397 http://dx.doi.org/10.3390/cells8060535 |
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author | Lee, Ho-Su Cleynen, Isabelle |
author_facet | Lee, Ho-Su Cleynen, Isabelle |
author_sort | Lee, Ho-Su |
collection | PubMed |
description | Inflammatory bowel disease (IBD) is a heterogeneous disorder in terms of age at onset, clinical phenotypes, severity, disease course, and response to therapy. This underlines the need for predictive and precision medicine that can optimize diagnosis and disease management, provide more cost-effective strategies, and minimize the risk of adverse events. Ideally, we can leverage molecular profiling to predict the risk to develop IBD and disease progression. Despite substantial successes of genome-wide association studies in the identification of genetic variants affecting IBD susceptibility, molecular profiling of disease onset and progression as well as of treatment responses has lagged behind. Still, thanks to technological advances and good study designs, predicting phenotypes using genomics and transcriptomics in IBD has been rapidly evolving. In this review, we summarize the current status of prediction of disease risk, clinical course, and response to therapy based on clinical case presentations. We also discuss the potential and limitations of the currently used approaches. |
format | Online Article Text |
id | pubmed-6627070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66270702019-07-19 Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making? Lee, Ho-Su Cleynen, Isabelle Cells Review Inflammatory bowel disease (IBD) is a heterogeneous disorder in terms of age at onset, clinical phenotypes, severity, disease course, and response to therapy. This underlines the need for predictive and precision medicine that can optimize diagnosis and disease management, provide more cost-effective strategies, and minimize the risk of adverse events. Ideally, we can leverage molecular profiling to predict the risk to develop IBD and disease progression. Despite substantial successes of genome-wide association studies in the identification of genetic variants affecting IBD susceptibility, molecular profiling of disease onset and progression as well as of treatment responses has lagged behind. Still, thanks to technological advances and good study designs, predicting phenotypes using genomics and transcriptomics in IBD has been rapidly evolving. In this review, we summarize the current status of prediction of disease risk, clinical course, and response to therapy based on clinical case presentations. We also discuss the potential and limitations of the currently used approaches. MDPI 2019-06-04 /pmc/articles/PMC6627070/ /pubmed/31167397 http://dx.doi.org/10.3390/cells8060535 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lee, Ho-Su Cleynen, Isabelle Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making? |
title | Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making? |
title_full | Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making? |
title_fullStr | Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making? |
title_full_unstemmed | Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making? |
title_short | Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making? |
title_sort | molecular profiling of inflammatory bowel disease: is it ready for use in clinical decision-making? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627070/ https://www.ncbi.nlm.nih.gov/pubmed/31167397 http://dx.doi.org/10.3390/cells8060535 |
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