Cargando…

Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology

Circulating tumor cells (CTCs) and circulating tumor microemboli (CTM) have been shown to correlate negatively with patient survival. Actual CTC counts before and after treatment can be used to aid in the prognosis of patient outcomes. The presence of circulating tumor materials (CTMat) can advertis...

Descripción completa

Detalles Bibliográficos
Autores principales: Bailey, Patrick C., Martin, Stuart S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627072/
https://www.ncbi.nlm.nih.gov/pubmed/31174404
http://dx.doi.org/10.3390/cells8060553
_version_ 1783434653313531904
author Bailey, Patrick C.
Martin, Stuart S.
author_facet Bailey, Patrick C.
Martin, Stuart S.
author_sort Bailey, Patrick C.
collection PubMed
description Circulating tumor cells (CTCs) and circulating tumor microemboli (CTM) have been shown to correlate negatively with patient survival. Actual CTC counts before and after treatment can be used to aid in the prognosis of patient outcomes. The presence of circulating tumor materials (CTMat) can advertise the presence of metastasis before clinical presentation, enabling the early detection of relapse. Importantly, emerging evidence is indicating that cancer treatments can actually increase the incidence of CTCs and metastasis in pre-clinical models. Subsequently, the study of CTCs, their biology and function are of vital importance. Emerging technologies for the capture of CTC/CTMs and CTMat are elucidating vitally important biological and functional information that can lead to important alterations in how therapies are administered. This paves the way for the development of a “liquid biopsy” where treatment decisions can be informed by information gleaned from tumor cells and tumor cell debris in the blood.
format Online
Article
Text
id pubmed-6627072
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66270722019-07-19 Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology Bailey, Patrick C. Martin, Stuart S. Cells Review Circulating tumor cells (CTCs) and circulating tumor microemboli (CTM) have been shown to correlate negatively with patient survival. Actual CTC counts before and after treatment can be used to aid in the prognosis of patient outcomes. The presence of circulating tumor materials (CTMat) can advertise the presence of metastasis before clinical presentation, enabling the early detection of relapse. Importantly, emerging evidence is indicating that cancer treatments can actually increase the incidence of CTCs and metastasis in pre-clinical models. Subsequently, the study of CTCs, their biology and function are of vital importance. Emerging technologies for the capture of CTC/CTMs and CTMat are elucidating vitally important biological and functional information that can lead to important alterations in how therapies are administered. This paves the way for the development of a “liquid biopsy” where treatment decisions can be informed by information gleaned from tumor cells and tumor cell debris in the blood. MDPI 2019-06-06 /pmc/articles/PMC6627072/ /pubmed/31174404 http://dx.doi.org/10.3390/cells8060553 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bailey, Patrick C.
Martin, Stuart S.
Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology
title Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology
title_full Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology
title_fullStr Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology
title_full_unstemmed Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology
title_short Insights on CTC Biology and Clinical Impact Emerging from Advances in Capture Technology
title_sort insights on ctc biology and clinical impact emerging from advances in capture technology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627072/
https://www.ncbi.nlm.nih.gov/pubmed/31174404
http://dx.doi.org/10.3390/cells8060553
work_keys_str_mv AT baileypatrickc insightsonctcbiologyandclinicalimpactemergingfromadvancesincapturetechnology
AT martinstuarts insightsonctcbiologyandclinicalimpactemergingfromadvancesincapturetechnology