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MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer

The family of MOBs (monopolar spindle-one-binder proteins) is highly conserved in the eukaryotic kingdom. MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers in essential intracellular pathways. MOBs have diverse cancer-associated cell...

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Detalles Bibliográficos
Autores principales: Gundogdu, Ramazan, Hergovich, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627106/
https://www.ncbi.nlm.nih.gov/pubmed/31185650
http://dx.doi.org/10.3390/cells8060569
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author Gundogdu, Ramazan
Hergovich, Alexander
author_facet Gundogdu, Ramazan
Hergovich, Alexander
author_sort Gundogdu, Ramazan
collection PubMed
description The family of MOBs (monopolar spindle-one-binder proteins) is highly conserved in the eukaryotic kingdom. MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers in essential intracellular pathways. MOBs have diverse cancer-associated cellular functions through regulatory interactions with members of the NDR/LATS kinase family. By forming additional complexes with serine/threonine protein kinases of the germinal centre kinase families, other enzymes and scaffolding factors, MOBs appear to be linked to an even broader disease spectrum. Here, we review our current understanding of this emerging protein family, with emphases on post-translational modifications, protein-protein interactions, and cellular processes that are possibly linked to cancer and other diseases. In particular, we summarise the roles of MOBs as core components of the Hippo tissue growth and regeneration pathway.
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spelling pubmed-66271062019-07-19 MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer Gundogdu, Ramazan Hergovich, Alexander Cells Review The family of MOBs (monopolar spindle-one-binder proteins) is highly conserved in the eukaryotic kingdom. MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers in essential intracellular pathways. MOBs have diverse cancer-associated cellular functions through regulatory interactions with members of the NDR/LATS kinase family. By forming additional complexes with serine/threonine protein kinases of the germinal centre kinase families, other enzymes and scaffolding factors, MOBs appear to be linked to an even broader disease spectrum. Here, we review our current understanding of this emerging protein family, with emphases on post-translational modifications, protein-protein interactions, and cellular processes that are possibly linked to cancer and other diseases. In particular, we summarise the roles of MOBs as core components of the Hippo tissue growth and regeneration pathway. MDPI 2019-06-10 /pmc/articles/PMC6627106/ /pubmed/31185650 http://dx.doi.org/10.3390/cells8060569 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gundogdu, Ramazan
Hergovich, Alexander
MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer
title MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer
title_full MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer
title_fullStr MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer
title_full_unstemmed MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer
title_short MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer
title_sort mob (mps one binder) proteins in the hippo pathway and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627106/
https://www.ncbi.nlm.nih.gov/pubmed/31185650
http://dx.doi.org/10.3390/cells8060569
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