Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of N-acetyl-cysteine and β-mercaptoethylamine

Glutathione (GSH) has poor pharmacokinetic properties; thus, several derivatives and biosynthetic precursors have been proposed as GSH-boosting drugs. I-152 is a conjugate of N-acetyl-cysteine (NAC) and S-acetyl-β-mercaptoethylamine (SMEA) designed to release the parent drugs (i.e., NAC and β-mercap...

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Detalles Bibliográficos
Autores principales: Crinelli, Rita, Zara, Carolina, Smietana, Michaël, Retini, Michele, Magnani, Mauro, Fraternale, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627109/
https://www.ncbi.nlm.nih.gov/pubmed/31181621
http://dx.doi.org/10.3390/nu11061291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627109/
https://www.ncbi.nlm.nih.gov/pubmed/31181621
http://dx.doi.org/10.3390/nu11061291

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